Seroatlas · Human Serome Atlas

CSTF2T

Cleavage stimulation factor subunit 2 tau variant

Also known as: CstF-64T, CSTFT_HUMAN, DKFZp434C1013, KIAA0689, tauCstF-64

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0L4
Gene
CSTF2T
Ensembl
ENSG00000177613
Chromosome
10
Canonical length
616 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Basal body

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in mRNA 3'-end processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

616 residues, UniProt reviewed canonical sequence.

>Q9H0L4|CSTF2T
     1  MSSLAVRDPA MDRSLRSVFV GNIPYEATEE QLKDIFSEVG SVVSFRLVYD RETGKPKGYG
    61  FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGPAAPI IDSPYGDPID
   121  PEDAPESITR AVASLPPEQM FELMKQMKLC VQNSHQEARN MLLQNPQLAY ALLQAQVVMR
   181  IMDPEIALKI LHRKIHVTPL IPGKSQSVSV SGPGPGPGPG LCPGPNVLLN QQNPPAPQPQ
   241  HLARRPVKDI PPLMQTPIQG GIPAPGPIPA AVPGAGPGSL TPGGAMQPQL GMPGVGPVPL
   301  ERGQVQMSDP RAPIPRGPVT PGGLPPRGLL GDAPNDPRGG TLLSVTGEVE PRGYLGPPHQ
   361  GPPMHHASGH DTRGPSSHEM RGGPLGDPRL LIGEPRGPMI DQRGLPMDGR GGRDSRAMET
   421  RAMETEVLET RVMERRGMET CAMETRGMEA RGMDARGLEM RGPVPSSRGP MTGGIQGPGP
   481  INIGAGGPPQ GPRQVPGISG VGNPGAGMQG TGIQGTGMQG AGIQGGGMQG AGIQGVSIQG
   541  GGIQGGGIQG ASKQGGSQPS SFSPGQSQVT PQDQEKAALI MQVLQLTADQ IAMLPPEQRQ
   601  SILILKEQIQ KSTGAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSTF2T can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 21 nTPM
  • skeletal muscle: 21 nTPM
  • thymus: 20 nTPM
  • lymph node: 18 nTPM
  • tonsil: 18 nTPM
  • parathyroid gland: 17 nTPM

Single-cell type

  • cardiomyocytes: 43 nCPM
  • early primary spermatocytes: 37 nCPM
  • cytotrophoblasts: 29 nCPM
  • thymic myoid cells: 29 nCPM
  • erythrocyte progenitors: 27 nCPM
  • smooth muscle cells: 26 nCPM

Immune cell

  • NK-cell: 11 nTPM
  • MAIT T-cell: 4.9 nTPM
  • T-reg: 4.6 nTPM
  • eosinophil: 4.5 nTPM
  • naive CD4 T-cell: 4.4 nTPM
  • myeloid DC: 4.3 nTPM

Brain region

  • white matter: 34 nTPM
  • spinal cord: 26 nTPM
  • cerebellum: 25 nTPM
  • medulla oblongata: 25 nTPM
  • pons: 25 nTPM
  • basal ganglia: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.09
gnomAD missense Z
0.9
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSTF2T in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSTF2T as an antibody target. Whether an autoantibody or antibody against CSTF2T could matter depends on whether native CSTF2T is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSTF2T is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSTF2T as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSTF2T. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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