Seroatlas · Human Serome Atlas

MSI1

RNA-binding protein Musashi homolog 1

Also known as: MSI1H_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43347
Gene: MSI1
Ensembl: ENSG00000135097
Chromosome: 12
Canonical length: 362 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>O43347|MSI1
     1  METDAPQPGL ASPDSPHDPC KMFIGGLSWQ TTQEGLREYF GQFGEVKECL VMRDPLTKRS
    61  RGFGFVTFMD QAGVDKVLAQ SRHELDSKTI DPKVAFPRRA QPKMVTRTKK IFVGGLSVNT
   121  TVEDVKQYFE QFGKVDDAML MFDKTTNRHR GFGFVTFESE DIVEKVCEIH FHEINNKMVE
   181  CKKAQPKEVM SPTGSARGRS RVMPYGMDAF MLGIGMLGYP GFQATTYASR SYTGLAPGYT
   241  YQFPEFRVER TPLPSAPVLP ELTAIPLTAY GPMAAAAAAA AVVRGTGSHP WTMAPPPGST
   301  PSRTGGFLGT TSPGPMAELY GAANQDSGVS SYISAASPAP STGFGHSLGG PLIATAFTNG
   361  YH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

retina: 97 nTPM
skeletal muscle: 21 nTPM
testis: 15 nTPM
pituitary gland: 13 nTPM
choroid plexus: 10 nTPM
cerebral cortex: 9.4 nTPM

Single-cell type

rod photoreceptor cells: 186 nCPM
müller glia: 135 nCPM
cone photoreceptor cells: 99 nCPM
late spermatids: 92 nCPM
early spermatids: 73 nCPM
retinal pigment epithelial cells: 64 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 38 nTPM
midbrain: 29 nTPM
medulla oblongata: 28 nTPM
thalamus: 25 nTPM
hippocampal formation: 24 nTPM
amygdala: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.99
gnomAD missense Z: 2.8
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSI1 as an antibody target. Whether an autoantibody or antibody against MSI1 could matter depends on whether native MSI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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