Seroatlas · Human Serome Atlas

TUT1

Speckle targeted PIP5K1A-regulated poly(A) polymerase

Also known as: FLJ21850, FLJ22267, FLJ22347, PAPD2, RBM21, STPAP_HUMAN, TENT1, TUTase

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H6E5
Gene
TUT1
Ensembl
ENSG00000149016
Chromosome
11
Canonical length
874 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

874 residues, UniProt reviewed canonical sequence.

>Q9H6E5|TUT1
     1  MAAVDSDVES LPRGGFRCCL CHVTTANRPS LDAHLGGRKH RHLVELRAAR KAQGLRSVFV
    61  SGFPRDVDSA QLSEYFLAFG PVASVVMDKD KGVFAIVEMG DVGAREAVLS QSQHSLGGHR
   121  LRVRPREQKE FQSPASKSPK GAAPDSHQLA KALAEAADVG AQMIKLVGLR ELSEAERQLR
   181  SLVVALMQEV FTEFFPGCVV HPFGSSINSF DVHGCDLDLF LDLGDLEEPQ PVPKAPESPS
   241  LDSALASPLD PQALACTPAS PPDSQPPASP QDSEALDFET PSSSLAPQTP DSALASETLA
   301  SPQSLPPASP LLEDREEGDL GKASELAETP KEEKAEGAAM LELVGSILRG CVPGVYRVQT
   361  VPSARRPVVK FCHRPSGLHG DVSLSNRLAL HNSRFLSLCS ELDGRVRPLV YTLRCWAQGR
   421  GLSGSGPLLS NYALTLLVIY FLQTRDPPVL PTVSQLTQKA GEGEQVEVDG WDCSFPRDAS
   481  RLEPSINVEP LSSLLAQFFS CVSCWDLRGS LLSLREGQAL PVAGGLPSNL WEGLRLGPLN
   541  LQDPFDLSHN VAANVTSRVA GRLQNCCRAA ANYCRSLQYQ RRSSRGRDWG LLPLLQPSSP
   601  SSLLSATPIP LPLAPFTQLT AALVQVFREA LGCHIEQATK RTRSEGGGTG ESSQGGTSKR
   661  LKVDGQKNCC EEGKEEQQGC AGDGGEDRVE EMVIEVGEMV QDWAMQSPGQ PGDLPLTTGK
   721  HGAPGEEGQP SHAALAERGP KGHEAAQEWS QGEAGKGASL PSSASWRCAL WHRVWQGRRR
   781  ARRRLQQQTK EGAGGGAGTR AGWLATEAQV TQELKGLSGG EERPETEPLL SFVASVSPAD
   841  RMLTVTPLQD PQGLFPDLHH FLQVFLPQAI RHLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • liver: 23 nTPM
  • skeletal muscle: 20 nTPM
  • pancreas: 20 nTPM
  • testis: 14 nTPM
  • spleen: 13 nTPM
  • prostate: 13 nTPM

Single-cell type

  • choroid plexus epithelial cells: 6.7 nCPM
  • bergmann glia: 5.2 nCPM
  • ependymal cells: 4.1 nCPM
  • oligodendrocytes: 4 nCPM
  • other brain neurons: 4 nCPM
  • astrocytes: 3.8 nCPM

Immune cell

  • naive CD4 T-cell: 14 nTPM
  • MAIT T-cell: 14 nTPM
  • naive CD8 T-cell: 12 nTPM
  • naive B-cell: 12 nTPM
  • NK-cell: 11 nTPM
  • gdT-cell: 9.9 nTPM

Brain region

  • white matter: 19 nTPM
  • medulla oblongata: 16 nTPM
  • pons: 16 nTPM
  • basal ganglia: 15 nTPM
  • thalamus: 15 nTPM
  • spinal cord: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUT1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 171 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
0.42
DepMap mean gene effect
-1.79
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUT1 as an antibody target. Whether an autoantibody or antibody against TUT1 could matter depends on whether native TUT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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