Seroatlas · Human Serome Atlas

HNRNPAB

Heterogeneous nuclear ribonucleoprotein A/B

Also known as: ABBP1, FLJ40338, HNRPAB, ROAA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99729
Gene
HNRNPAB
Ensembl
ENSG00000197451
Chromosome
5
Canonical length
332 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>Q99729|HNRNPAB
     1  MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN QNGAEGDQIN
    61  ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI KMDPNTGRSR GFGFILFKDA
   121  ASVEKVLDQK EHRLDGRVID PKKAMAMKKD PVKKIFVGGL NPESPTEEKI REYFGEFGEI
   181  EAIELPMDPK LNKRRGFVFI TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY
   241  GSGGRGNRNR GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY
   301  YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPAB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
136 nTPM

Expression across tissuesHPA

Tissue

  • colon: 136 nTPM
  • bone marrow: 132 nTPM
  • esophagus: 118 nTPM
  • skeletal muscle: 114 nTPM
  • urinary bladder: 114 nTPM
  • rectum: 112 nTPM

Single-cell type

  • erythrocyte progenitors: 647 nCPM
  • megakaryocyte progenitors: 369 nCPM
  • megakaryocyte-erythroid progenitors: 340 nCPM
  • suprabasal keratinocytes: 340 nCPM
  • monocyte progenitors: 331 nCPM
  • esophageal basal cells: 305 nCPM

Immune cell

  • eosinophil: 16 nTPM
  • plasmacytoid DC: 11 nTPM
  • non-classical monocyte: 7.5 nTPM
  • intermediate monocyte: 7 nTPM
  • memory CD8 T-cell: 6 nTPM
  • memory B-cell: 5.9 nTPM

Brain region

  • hypothalamus: 47 nTPM
  • white matter: 46 nTPM
  • medulla oblongata: 44 nTPM
  • choroid plexus: 44 nTPM
  • thalamus: 43 nTPM
  • pons: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.77
gnomAD missense Z
1.13
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPAB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPAB as an antibody target. Whether an autoantibody or antibody against HNRNPAB could matter depends on whether native HNRNPAB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPAB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPAB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HNRNPAB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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