Seroatlas · Human Serome Atlas

RBM45

RNA-binding protein 45

Also known as: DRB1, FLJ44612, RBM45_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IUH3
Gene: RBM45
Ensembl: ENSG00000155636
Chromosome: 2
Canonical length: 476 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q8IUH3|RBM45
     1  MDEAGSSASG GGFRPGVDSL DEPPNSRIFL VISKYTPESV LRERFSPFGD IQDIWVVRDK
    61  HTKESKGIAF VKFARSSQAC RAMEEMHGQC LGPNDTKPIK VFIAQSRSSG SHRDVEDEEL
   121  TRIFVMIPKS YTEEDLREKF KVYGDIEYCS IIKNKVTGES KGLGYVRYLK PSQAAQAIEN
   181  CDRSFRAILA EPKNKASESS EQDYYSNMRQ EALGHEPRVN MFPFVGEQQS EFSSFDKNDS
   241  RGQEAISKRL SVVSRVPFTE EQLFSIFDIV PGLEYCEVQR DPYSNYGHGV VQYFNVASAI
   301  YAKYKLHGFQ YPPGNRIGVS FIDDGSNATD LLRKMATQMV AAQLASMVWN NPSQQQFMQF
   361  GGSSGSQLPQ IQTDVVLPSC KKKAPAETPV KERLFIVFNP HPLPLDVLED IFCRFGNLIE
   421  VYLVSGKNVG YAKYADRISA NDAIATLHGK ILNGVRLKVM LADSPREESN KRQRTY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 15 nTPM
tonsil: 9.3 nTPM
retina: 9 nTPM
epididymis: 8.7 nTPM
rectum: 8.7 nTPM
parathyroid gland: 8.2 nTPM

Single-cell type

sertoli cells: 59 nCPM
corticotrophs: 43 nCPM
microglia: 42 nCPM
oligodendrocyte progenitor cells: 40 nCPM
oligodendrocytes: 39 nCPM
ependymal cells: 35 nCPM

Immune cell

memory B-cell: 13 nTPM
NK-cell: 11 nTPM
T-reg: 11 nTPM
non-classical monocyte: 10 nTPM
intermediate monocyte: 8.6 nTPM
naive B-cell: 8.6 nTPM

Brain region

white matter: 8.3 nTPM
medulla oblongata: 8 nTPM
hypothalamus: 7.8 nTPM
pons: 7.7 nTPM
basal ganglia: 7.6 nTPM
choroid plexus: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 1.66
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
SRA stem-loop-interacting RNA-binding protein/Glycine-rich RNA-binding-like
RNA recognition motif
RBM45, RNA recognition motif 1
RBM45, RNA recognition motif 2
RBM45, RNA recognition motif 3
RBM45, RNA recognition motif 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM45 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM45 as an antibody target. Whether an autoantibody or antibody against RBM45 could matter depends on whether native RBM45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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