Seroatlas · Human Serome Atlas

RBM18

Probable RNA-binding protein 18

Also known as: MGC2734, RBM18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96H35
Gene: RBM18
Ensembl: ENSG00000119446
Chromosome: 9
Canonical length: 190 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Predicted to enable RNA binding activity. Located in cytosol; intercellular bridge; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>Q96H35|RBM18
     1  MEAETKTLPL ENASILSEGS LQEGHRLWIG NLDPKITEYH LLKLLQKFGK VKQFDFLFHK
    61  SGALEGQPRG YCFVNFETKQ EAEQAIQCLN GKLALSKKLV VRWAHAQVKR YDHNKNDKIL
   121  PISLEPSSST EPTQSNLSVT AKIKAIEAKL KMMAENPDAE YPAAPVYSYF KPPDKKRTTP
   181  YSRTAWKSRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

tongue: 22 nTPM
skeletal muscle: 19 nTPM
breast: 15 nTPM
heart muscle: 13 nTPM
bone marrow: 11 nTPM
parathyroid gland: 11 nTPM

Single-cell type

late spermatids: 107 nCPM
early spermatids: 82 nCPM
syncytiotrophoblasts: 75 nCPM
oocytes: 60 nCPM
extravillous trophoblasts: 58 nCPM
late primary spermatocytes: 52 nCPM

Immune cell

eosinophil: 11 nTPM
non-classical monocyte: 9.8 nTPM
intermediate monocyte: 7.2 nTPM
myeloid DC: 6.5 nTPM
neutrophil: 6.5 nTPM
T-reg: 6.4 nTPM

Brain region

hypothalamus: 12 nTPM
cerebral cortex: 11 nTPM
pons: 11 nTPM
white matter: 11 nTPM
medulla oblongata: 10 nTPM
cerebellum: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA recognition motif
RNA-binding protein 18, RNA recognition motif

KeywordsUniProt

RNA-binding

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM18 as an antibody target. Whether an autoantibody or antibody against RBM18 could matter depends on whether native RBM18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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