CPEB2

Protein identityUniProt · HPA

UniProt accession

Q7Z5Q1

Gene

CPEB2

Ensembl

ENSG00000137449

Chromosome

4

Canonical length

589 aa

Protein class

Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

589 residues, UniProt reviewed canonical sequence.

>Q7Z5Q1|CPEB2
     1  MPPPSPDSEN GFYPGLPSSM NPAFFPSFSP VSPHGCTGLS VPTSGGGGGG FGGPFSATAV
    61  PPPPPPAMNI PQQQPPPPAA PQQPQSRRSP VSPQLQQQHQ AAAAAFLQQR NSYNHHQPLL
   121  KQSPWSNHQS SGWGTGSMSW GAMHGRDHRR TGNMGIPGTM NQISPLKKPF SGNVIAPPKF
   181  TRSTPSLTPK SWIEDNVFRT DNNSNTLLPL QVRSSLQLPA WGSDSLQDSW CTAAGTSRID
   241  QDRSRMYDSL NMHSLENSLI DIMRAEHDPL KGRLSYPHPG TDNLLMLNGR SSLFPIDDGL
   301  LDDGHSDQVG VLNSPTCYSA HQNGERIERF SRKVFVGGLP PDIDEDEITA SFRRFGPLVV
   361  DWPHKAESKS YFPPKGYAFL LFQEESSVQA LIDACIEEDG KLYLCVSSPT IKDKPVQIRP
   421  WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP LRAVELAMIM DRLYGGVCYA GIDTDPELKY
   481  PKGAGRVAFS NQQSYIAAIS ARFVQLQHGD IDKRVEVKPY VLDDQMCDEC QGARCGGKFA
   541  PFFCANVTCL QYYCEFCWAN IHSRAGREFH KPLVKEGADR PRQIHFRWN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPEB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

35 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.59

gnomAD pLI

0

gnomAD missense Z

0.68

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to hypoxia
• cellular response to insulin stimulus
• negative regulation of cytoplasmic translation
• negative regulation of cytoplasmic translational elongation

Molecular functions

• GTPase inhibitor activity
• mRNA 3'-UTR AU-rich region binding
• mRNA 3'-UTR binding
• mRNA regulatory element binding translation repressor activity
• ribosomal large subunit binding
• ribosomal small subunit binding
• ribosome binding
• RNA binding
• translation factor activity, RNA binding

Cellular components

• cytoplasm
• neuron projection
• nucleus
• synapse

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• Nucleotide-binding alpha-beta plait domain superfamily
• Cytoplasmic polyadenylation element-binding protein, ZZ domain
• Cytoplasmic polyadenylation element-binding protein
• RNA-binding domain superfamily
• CEBP, ZZ domain superfamily
• Cytoplasmic polyadenylation element-binding protein ZZ domain
• RNA recognition motif

KeywordsUniProt

• Cytoplasm
• Phosphoprotein
• Repeat
• RNA-binding
• Translation regulation

InteractionsUniProt · HPA

Protein binding partners of CPEB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TENT2