Seroatlas · Human Serome Atlas

SLIRP

SRA stem-loop-interacting RNA-binding protein, mitochondrial

Also known as: C14orf156, DC50, SLIRP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZT3
Gene: SLIRP
Ensembl: ENSG00000119705
Chromosome: 14
Canonical length: 109 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

109 residues, UniProt reviewed canonical sequence.

>Q9GZT3|SLIRP
     1  MAASAARGAA ALRRSINQPV AFVRRIPWTA ASSQLKEHFA QFGHVRRCIL PFDKETGFHR
    61  GLGWVQFSSE EGLRNALQQE NHIIDGVKVQ VHTRRPKLPQ TSDDEKKDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLIRP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 412 nTPM

Expression across tissuesHPA

Tissue

tongue: 412 nTPM
skeletal muscle: 392 nTPM
heart muscle: 375 nTPM
amygdala: 309 nTPM
cerebral cortex: 275 nTPM
basal ganglia: 270 nTPM

Single-cell type

late primary spermatocytes: 951 nCPM
parietal cells: 879 nCPM
hepatocytes: 877 nCPM
gastric progenitor cells: 699 nCPM
oocytes: 580 nCPM
gastric chief cells: 558 nCPM

Immune cell

non-classical monocyte: 291 nTPM
classical monocyte: 278 nTPM
intermediate monocyte: 277 nTPM
plasmacytoid DC: 248 nTPM
myeloid DC: 241 nTPM
total PBMC: 217 nTPM

Brain region

white matter: 126 nTPM
hypothalamus: 111 nTPM
medulla oblongata: 110 nTPM
basal ganglia: 109 nTPM
cerebellum: 108 nTPM
spinal cord: 105 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.57
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLIRP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLIRP as an antibody target. Whether an autoantibody or antibody against SLIRP could matter depends on whether native SLIRP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLIRP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLIRP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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