Seroatlas · Human Serome Atlas

G3BP1

Ras GTPase-activating protein-binding protein 1

Also known as: G3BP, G3BP1_HUMAN, HDH-VIII

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13283
Gene
G3BP1
Ensembl
ENSG00000145907
Chromosome
5
Canonical length
466 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q13283|G3BP1
     1  MVMEKPSPLL VGREFVRQYY TLLNQAPDML HRFYGKNSSY VHGGLDSNGK PADAVYGQKE
    61  IHRKVMSQNF TNCHTKIRHV DAHATLNDGV VVQVMGLLSN NNQALRRFMQ TFVLAPEGSV
   121  ANKFYVHNDI FRYQDEVFGG FVTEPQEESE EEVEEPEERQ QTPEVVPDDS GTFYDQAVVS
   181  NDMEEHLEEP VAEPEPDPEP EPEQEPVSEI QEEKPEPVLE ETAPEDAQKS SSPAPADIAQ
   241  TVQEDLRTFS WASVTSKNLP PSGAVPVTGI PPHVVKVPAS QPRPESKPES QIPPQRPQRD
   301  QRVREQRINI PPQRGPRPIR EAGEQGDIEP RRMVRHPDSH QLFIGNLPHE VDKSELKDFF
   361  QSYGNVVELR INSGGKLPNF GFVVFDDSEP VQKVLSNRPI MFRGEVRLNV EEKKTRAARE
   421  GDRRDNRLRG PGGPRGGLGG GMRGPPRGGM VQKPGFGVGR GLAPRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against G3BP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 105 nTPM
  • tongue: 86 nTPM
  • tonsil: 80 nTPM
  • lymph node: 73 nTPM
  • liver: 65 nTPM
  • urinary bladder: 62 nTPM

Single-cell type

  • basal keratinocytes: 260 nCPM
  • suprabasal keratinocytes: 237 nCPM
  • erythrocyte progenitors: 235 nCPM
  • hepatocytes: 220 nCPM
  • megakaryocyte progenitors: 184 nCPM
  • ocular epithelial cells: 169 nCPM

Immune cell

  • total PBMC: 288 nTPM
  • MAIT T-cell: 256 nTPM
  • T-reg: 250 nTPM
  • memory CD4 T-cell: 216 nTPM
  • NK-cell: 205 nTPM
  • naive CD4 T-cell: 203 nTPM

Brain region

  • white matter: 82 nTPM
  • choroid plexus: 81 nTPM
  • cerebellum: 78 nTPM
  • thalamus: 77 nTPM
  • medulla oblongata: 71 nTPM
  • midbrain: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.03
gnomAD missense Z
1.86
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of G3BP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads G3BP1 as an antibody target. Whether an autoantibody or antibody against G3BP1 could matter depends on whether native G3BP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

G3BP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label G3BP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/G3BP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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