Seroatlas · Human Serome Atlas

FUS

RNA-binding protein FUS

Also known as: ALS6, FUS_HUMAN, FUS1, hnRNP-P2, HNRNPP2, TLS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35637
Gene
FUS
Ensembl
ENSG00000089280
Chromosome
16
Canonical length
526 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

526 residues, UniProt reviewed canonical sequence.

>P35637|FUS
     1  MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY GQSSYSSYGQ
    61  SQNTGYGTQS TPQGYGSTGG YGSSQSSQSS YGQQSSYPGY GQQPAPSSTS GSYGSSSQSS
   121  SYGQPQSGSY SQQPSYGGQQ QSYGQQQSYN PPQGYGQQNQ YNSSSGGGGG GGGGGNYGQD
   181  QSSMSSGGGS GGGYGNQDQS GGGGSGGYGQ QDRGGRGRGG SGGGGGGGGG GYNRSSGGYE
   241  PRGRGGGRGG RGGMGGSDRG GFNKFGGPRD QGSRHDSEQD NSDNNTIFVQ GLGENVTIES
   301  VADYFKQIGI IKTNKKTGQP MINLYTDRET GKLKGEATVS FDDPPSAKAA IDWFDGKEFS
   361  GNPIKVSFAT RRADFNRGGG NGRGGRGRGG PMGRGGYGGG GSGGGGRGGF PSGGGGGGGQ
   421  QRAGDWKCPN PTCENMNFSW RNECNQCKAP KPDGPGGGPG GSHMGGNYGD DRRGGRGGYD
   481  RGGYRGRGGD RGGFRGGRGG GDRGGFGPGK MDSRGEHRQD RRERPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
162 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 162 nTPM
  • ovary: 148 nTPM
  • cerebellum: 122 nTPM
  • skeletal muscle: 113 nTPM
  • endometrium: 109 nTPM
  • tonsil: 106 nTPM

Single-cell type

  • sertoli cells: 564 nCPM
  • extravillous trophoblasts: 511 nCPM
  • epididymal basal cells: 433 nCPM
  • leydig cells: 393 nCPM
  • ovarian stromal cells: 393 nCPM
  • migrating cytotrophoblasts: 379 nCPM

Immune cell

  • intermediate monocyte: 67 nTPM
  • non-classical monocyte: 60 nTPM
  • gdT-cell: 54 nTPM
  • eosinophil: 53 nTPM
  • plasmacytoid DC: 50 nTPM
  • MAIT T-cell: 50 nTPM

Brain region

  • cerebral cortex: 93 nTPM
  • cerebellum: 82 nTPM
  • white matter: 82 nTPM
  • hypothalamus: 79 nTPM
  • basal ganglia: 77 nTPM
  • pons: 74 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FUS.

Disease | AllUniProt

Conditions FUS is implicated in, by any mechanism.

  • Angiomatoid fibrous histiocytoma (AFH) MIM:612160
  • Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia (ALS6) MIM:608030
  • Tremor, hereditary essential 4 (ETM4) MIM:614782

Disease | GeneticClinVar

51 pathogenic / likely-pathogenic of 683 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on FUS was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
2.21
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FUS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUS as an antibody target. Whether an autoantibody or antibody against FUS could matter depends on whether native FUS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FUS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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