Seroatlas · Human Serome Atlas

SRSF12

Serine/arginine-rich splicing factor 12

Also known as: SFRS13B, SFRS19, SRrp35, SRS12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXF0
Gene: SRSF12
Ensembl: ENSG00000154548
Chromosome: 6
Canonical length: 261 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Involved in mRNA 5'-splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q8WXF0|SRSF12
     1  MSRYTRPPNT SLFIRNVADA TRPEDLRREF GRYGPIVDVY IPLDFYTRRP RGFAYVQFED
    61  VRDAEDALYN LNRKWVCGRQ IEIQFAQGDR KTPGQMKSKE RHPCSPSDHR RSRSPSQRRT
   121  RSRSSSWGRN RRRSDSLKES RHRRFSYSQS KSRSKSLPRR STSARQSRTP RRNFGSRGRS
   181  RSKSLQKRSK SIGKSQSSSP QKQTSSGTKS RSHGRHSDSI ARSPCKSPKG YTNSETKVQT
   241  AKHSHFRSHS RSRSYRHKNS W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSF12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
cerebral cortex: 4.1 nTPM
hypothalamus: 3.8 nTPM
amygdala: 3.6 nTPM
basal ganglia: 3.2 nTPM
cerebellum: 3.2 nTPM

Single-cell type

late spermatids: 332 nCPM
epicardial cells: 307 nCPM
late primary spermatocytes: 188 nCPM
early spermatids: 155 nCPM
undifferentiated spermatogonia: 69 nCPM
differentiating spermatogonia: 65 nCPM

Immune cell

NK-cell: 0.5 nTPM
basophil: 0.2 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

hypothalamus: 11 nTPM
cerebellum: 11 nTPM
basal ganglia: 9.4 nTPM
cerebral cortex: 9.4 nTPM
hippocampal formation: 8.3 nTPM
midbrain: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.03
gnomAD missense Z: 1.11
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSF12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SRPK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSF12 as an antibody target. Whether an autoantibody or antibody against SRSF12 could matter depends on whether native SRSF12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSF12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSF12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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