DND1

Protein identityUniProt · HPA

UniProt accession

Q8IYX4

Gene

DND1

Ensembl

ENSG00000256453

Chromosome

5

Canonical length

353 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Focal adhesion sites,Cytosol

OverviewNCBI Gene

This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>Q8IYX4|DND1
     1  MQSKRDCELW CERVNPENKA ALEAWVRETG IRLVQVNGQR KYGGPPPGWV GSPPPAGSEV
    61  FIGRLPQDVY EHQLIPLFQR VGRLYEFRLM MTFSGLNRGF AYARYSSRRG AQAAIATLHN
   121  HPLRPSCPLL VCRSTEKCEL SVDGLPPNLT RSALLLALQP LGPGLQEARL LPSPGPAPGQ
   181  IALLKFSSHR AAAMAKKALV EGQSHLCGEQ VAVEWLKPDL KQRLRQQLVG PFLRSPQPEG
   241  SQLALARDKL GFQGARATLQ LLCQRMKLGS PVFLTKCLGI GPAGWHRFWY QVVIPGHPVP
   301  FSGLIWVVLT LDGRDGHEVA KDAVSVRLLQ ALSESGANLL WSAGAEAGTM VKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.55

gnomAD pLI

0.44

gnomAD missense Z

2.22

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 3'-UTR-mediated mRNA destabilization
• germ cell development
• mRNA stabilization
• negative regulation of miRNA-mediated gene silencing
• spermatogenesis

Molecular functions

• mRNA 3'-UTR binding
• mRNA binding

Cellular components

• cytoplasm
• cytosol
• focal adhesion
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• RNA recognition motif
• double strand RNA binding domain from DEAD END PROTEIN 1
• Dead end protein 1, RNA recognition motif 1
• DND1, double-stranded RNA binding domain

KeywordsUniProt

• Cytoplasm
• Developmental protein
• Nucleus
• Repeat
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of DND1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APOBEC3