Seroatlas · Human Serome Atlas

RBM14

RNA-binding protein 14

Also known as: COAA, DKFZp779J0927, RBM14_HUMAN, SIP, SYTIP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PK6
Gene
RBM14
Ensembl
ENSG00000239306
Chromosome
11
Canonical length
669 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

669 residues, UniProt reviewed canonical sequence.

>Q96PK6|RBM14
     1  MKIFVGNVDG ADTTPEELAA LFAPYGTVMS CAVMKQFAFV HMRENAGALR AIEALHGHEL
    61  RPGRALVVEM SRPRPLNTWK IFVGNVSAAC TSQELRSLFE RRGRVIECDV VKDYAFVHME
   121  KEADAKAAIA QLNGKEVKGK RINVELSTKG QKKGPGLAVQ SGDKTKKPGA GDTAFPGTGG
   181  FSATFDYQQA FGNSTGGFDG QARQPTPPFF GRDRSPLRRS PPRASYVAPL TAQPATYRAQ
   241  PSVSLGAAYR AQPSASLGVG YRTQPMTAQA ASYRAQPSVS LGAPYRGQLA SPSSQSAAAS
   301  SLGPYGGAQP SASALSSYGG QAAAASSLNS YGAQGSSLAS YGNQPSSYGA QAASSYGVRA
   361  AASSYNTQGA ASSLGSYGAQ AASYGAQSAA SSLAYGAQAA SYNAQPSASY NAQSAPYAAQ
   421  QAASYSSQPA AYVAQPATAA AYASQPAAYA AQATTPMAGS YGAQPVVQTQ LNSYGAQASM
   481  GLSGSYGAQS AAAATGSYGA AAAYGAQPSA TLAAPYRTQS SASLAASYAA QQHPQAAASY
   541  RGQPGNAYDG AGQPSAAYLS MSQGAVANAN STPPPYERTR LSPPRASYDD PYKKAVAMSK
   601  RYGSDRRLAE LSDYRRLSES QLSFRRSPTK SSLDYRRLPD AHSDYARYSG SYNDYLRAAQ
   661  MHSGYQRRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 49 nTPM
  • ovary: 40 nTPM
  • kidney: 40 nTPM
  • testis: 39 nTPM
  • spleen: 38 nTPM
  • liver: 37 nTPM

Single-cell type

  • choroid plexus epithelial cells: 96 nCPM
  • microglia: 60 nCPM
  • ependymal cells: 49 nCPM
  • bergmann glia: 45 nCPM
  • astrocytes: 36 nCPM
  • brain inhibitory neurons: 35 nCPM

Immune cell

  • total PBMC: 34 nTPM
  • myeloid DC: 34 nTPM
  • naive CD8 T-cell: 28 nTPM
  • gdT-cell: 28 nTPM
  • eosinophil: 27 nTPM
  • non-classical monocyte: 27 nTPM

Brain region

  • cerebellum: 80 nTPM
  • choroid plexus: 73 nTPM
  • white matter: 70 nTPM
  • midbrain: 57 nTPM
  • cerebral cortex: 57 nTPM
  • hippocampal formation: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
2.11
DepMap mean gene effect
-1.26
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM14 as an antibody target. Whether an autoantibody or antibody against RBM14 could matter depends on whether native RBM14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBM14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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