DAZ4

Protein identityUniProt · HPA

UniProt accession

Q86SG3

Gene

DAZ4

Ensembl

ENSG00000205916

Chromosome

Y

Canonical length

579 aa

Protein class

Disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q86SG3|DAZ4
     1  MSAANPETPN STISREASTQ SSSAAASQGW VLPEGKIVPN TVFVGGIDAR MDETEIGSCF
    61  GRYGSVKEVK IITNRTGVSK GYGFVSFVND VDVQKIVGSQ IHFHGKKLKL GPAIRKQKLC
   121  ARHVQPRPLV VNPPPPPQFQ NVWRNPNTET YLQPQITPNP VTQHVQSAAN PETPNSTISR
   181  EASTQSSSAA ASQGWVLPEG KIVPNTVFVG GIDARMDETE IGSCFGRYGS VKEVKIITNR
   241  TGVSKGYGFV SFVNDVDVQK IVGSQIHFHG KKLKLGPAIR KQKLCARHVQ PRPLVVNPPP
   301  PPQFQNVWRN PNTETYLQPQ ITPNPVTQHV QAYSAYPHSP GQVITGCQLL VYNYQEYPTY
   361  PDSAFQVTTG YQLPVYNYQP FPAYPRSPFQ VTAGYQLPVY NYQAFPAYPN SPFQVATGYQ
   421  FPVYNYQPFP AYPSSPFQVT AGYQLPVYNY QAFPAYPNSP FQVATGYQFP VYNYQAFPAY
   481  PNSPVQVTTG YQLPVYNYQA FPAYPSSPFQ VTTGYQLPVY NYQAFPAYPN SAVQVTTGYQ
   541  FHVYNYQMPP QCPVGEQRRN LWTEAYKWWY LVCLIQRRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DAZ4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

24 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DAZ4.

Disease | AllUniProt

Conditions DAZ4 is implicated in, by any mechanism.

• Spermatogenic failure Y-linked 2 (SPGFY2) MIM:415000

OntologyGO

Biological processes

• 3'-UTR-mediated mRNA stabilization
• cell differentiation
• positive regulation of translational initiation
• spermatogenesis

Molecular functions

• mRNA 3'-UTR binding
• translation activator activity

Cellular components

• cytoplasm
• nucleus
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• DAZ, RNA recognition motif, vertebrates
• DAZ domain
• RNA recognition motif
• Daz repeat

KeywordsUniProt

• Cytoplasm
• Developmental protein
• Differentiation
• Nucleus
• Repeat
• RNA-binding
• Spermatogenesis

InteractionsUniProt · HPA

Protein binding partners of DAZ4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DAZAP1
• DAZAP2
• DZIP1
• DZIP3
• PUM2