Seroatlas · Human Serome Atlas

BRAP

BRCA1-associated protein

Also known as: BRAP_HUMAN, BRAP2, IMP, RNF52

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z569
Gene: BRAP
Ensembl: ENSG00000089234
Chromosome: 12
Canonical length: 592 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Nuclear membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>Q7Z569|BRAP
     1  MSVSLVVIRL ELAEHSPVPA GFGFSAAAGE MSDEEIKKTT LASAVACLEG KSPGEKVAII
    61  HQHLGRREMT DVIIETMKSN PDELKTTVEE RKSSEASPTA QRSKDHSKEC INAAPDSPSK
   121  QLPDQISFFS GNPSVEIVHG IMHLYKTNKM TSLKEDVRRS AMLCILTVPA AMTSHDLMKF
   181  VAPFNEVIEQ MKIIRDSTPN QYMVLIKFRA QADADSFYMT CNGRQFNSIE DDVCQLVYVE
   241  RAEVLKSEDG ASLPVMDLTE LPKCTVCLER MDESVNGILT TLCNHSFHSQ CLQRWDDTTC
   301  PVCRYCQTPE PVEENKCFEC GVQENLWICL ICGHIGCGRY VSRHAYKHFE ETQHTYAMQL
   361  TNHRVWDYAG DNYVHRLVAS KTDGKIVQYE CEGDTCQEEK IDALQLEYSY LLTSQLESQR
   421  IYWENKIVRI EKDTAEEINN MKTKFKETIE KCDNLEHKLN DLLKEKQSVE RKCTQLNTKV
   481  AKLTNELKEE QEMNKCLRAN QVLLQNKLKE EERVLKETCD QKDLQITEIQ EQLRDVMFYL
   541  ETQQKINHLP AETRQEIQEG QINIAMASAS SPASSGGSGK LPSRKGRSKR GK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

testis: 64 nTPM
bone marrow: 32 nTPM
skeletal muscle: 19 nTPM
tongue: 13 nTPM
skin: 12 nTPM
thymus: 12 nTPM

Single-cell type

late spermatids: 600 nCPM
late primary spermatocytes: 391 nCPM
early spermatids: 279 nCPM
oocytes: 115 nCPM
early primary spermatocytes: 72 nCPM
neutrophil progenitors: 65 nCPM

Immune cell

neutrophil: 33 nTPM
eosinophil: 32 nTPM
T-reg: 25 nTPM
NK-cell: 23 nTPM
basophil: 23 nTPM
memory CD4 T-cell: 19 nTPM

Brain region

white matter: 22 nTPM
cerebral cortex: 22 nTPM
cerebellum: 22 nTPM
midbrain: 21 nTPM
basal ganglia: 20 nTPM
hypothalamus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BRAP.

Disease | ImmuneIEDB

Conditions an epitope on BRAP was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0
gnomAD missense Z: 1.89
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, UBP-type
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type
RNA-binding domain superfamily
Zn-finger in ubiquitin-hydrolases and other protein
Ring finger domain
BRCA1-associated 2/ETP1, RRM
BRAP2, RNA recognition motif
BRCA1-associated protein, RING finger, H2 subclass
BRCA1-associated protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRAP as an antibody target. Whether an autoantibody or antibody against BRAP could matter depends on whether native BRAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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