Seroatlas · Human Serome Atlas

PTBP3

Polypyrimidine tract-binding protein 3

Also known as: DKFZp781I1117, PTBP3_HUMAN, ROD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95758
Gene
PTBP3
Ensembl
ENSG00000119314
Chromosome
9
Canonical length
552 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

552 residues, UniProt reviewed canonical sequence.

>O95758|PTBP3
     1  MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMNSSTPSTA NGNDSKKFKR DRPPCSPSRV
    61  LHLRKIPCDV TEAEIISLGL PFGKVTNLLM LKGKSQAFLE MASEEAAVTM VNYYTPITPH
   121  LRSQPVYIQY SNHRELKTDN LPNQARAQAA LQAVSAVQSG SLALSGGPSN EGTVLPGQSP
   181  VLRIIIENLF YPVTLEVLHQ IFSKFGTVLK IITFTKNNQF QALLQYADPV NAHYAKMALD
   241  GQNIYNACCT LRIDFSKLTS LNVKYNNDKS RDFTRLDLPT GDGQPSLEPP MAAAFGAPGI
   301  ISSPYAGAAG FAPAIGFPQA TGLSVPAVPG ALGPLTITSS AVTGRMAIPG ASGIPGNSVL
   361  LVTNLNPDLI TPHGLFILFG VYGDVHRVKI MFNKKENALV QMADANQAQL AMNHLSGQRL
   421  YGKVLRATLS KHQAVQLPRE GQEDQGLTKD FSNSPLHRFK KPGSKNFQNI FPPSATLHLS
   481  NIPPSVTVDD LKNLFIEAGC SVKAFKFFQK DRKMALIQLG SVEEAIQALI ELHNHDLGEN
   541  HHLRVSFSKS TI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTBP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 43 nTPM
  • bone marrow: 39 nTPM
  • tonsil: 37 nTPM
  • esophagus: 35 nTPM
  • urinary bladder: 35 nTPM
  • lymph node: 34 nTPM

Single-cell type

  • neutrophils: 996 nCPM
  • renal collecting duct principal cells: 751 nCPM
  • neutrophil progenitors: 647 nCPM
  • renal collecting duct intercalated cells: 580 nCPM
  • podocytes: 543 nCPM
  • esophageal apical cells: 516 nCPM

Immune cell

  • neutrophil: 33 nTPM
  • basophil: 23 nTPM
  • eosinophil: 17 nTPM
  • plasmacytoid DC: 16 nTPM
  • non-classical monocyte: 15 nTPM
  • MAIT T-cell: 11 nTPM

Brain region

  • hypothalamus: 34 nTPM
  • basal ganglia: 30 nTPM
  • cerebral cortex: 24 nTPM
  • white matter: 23 nTPM
  • midbrain: 23 nTPM
  • choroid plexus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.86
gnomAD missense Z
1.2
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTBP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTBP3 as an antibody target. Whether an autoantibody or antibody against PTBP3 could matter depends on whether native PTBP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTBP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTBP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTBP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...