RALYL
RNA-binding Raly-like protein
Also known as: HNRPCL3, RALYL_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86SE5
- Gene
- RALYL
- Ensembl
- ENSG00000184672
- Chromosome
- 8
- Canonical length
- 291 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Enables identical protein binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
291 residues, UniProt reviewed canonical sequence.
>Q86SE5|RALYL
1 MTGKTQTSNV TNKNDPKSIN SRVFIGNLNT AIVKKVDIEA IFSKYGKIVG CSVHKGYAFV
61 QYMSERHARA AVAGENARVI AGQPLDINMA GEPKPYRPKP GNKRPLSALY RLESKEPFLS
121 VGGYVFDYDY YRDDFYNRLF DYHGRVPPPP RAVIPLKRPR VAVTTTRRGK GVFSMKGGSR
181 STASGSTGSK LKSDELQTIK KELTQIKTKI DSLLGRLEKI EKQQKAEAEA QKKQLEESLV
241 LIQEECVSEI ADHSTEEPAE GGPDADGEEM TDGIEEDFDE DGGHELFLQI KLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RALYL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 53 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 53 nTPM
- hypothalamus: 42 nTPM
- cerebral cortex: 38 nTPM
- basal ganglia: 30 nTPM
- midbrain: 25 nTPM
- amygdala: 24 nTPM
Single-cell type
- adrenal cortex cells: 3,796 nCPM
- brain excitatory neurons: 2,787 nCPM
- other brain neurons: 2,387 nCPM
- adrenal medulla cells: 2,064 nCPM
- brain inhibitory neurons: 1,869 nCPM
- lactotrophs: 1,565 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 153 nTPM
- cerebral cortex: 94 nTPM
- basal ganglia: 76 nTPM
- white matter: 68 nTPM
- hypothalamus: 68 nTPM
- pons: 59 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.54
- gnomAD pLI
- 0.46
- gnomAD missense Z
- 0.93
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RALYL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RALYL as an antibody target. Whether an autoantibody or antibody against RALYL could matter depends on whether native RALYL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RALYL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RALYL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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