Seroatlas · Human Serome Atlas

RBM44

RNA-binding protein 44

Also known as: FLJ40411, RBM44_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZP01
Gene: RBM44
Ensembl: ENSG00000177483
Chromosome: 2
Canonical length: 1051 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable protein homodimerization activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytoplasm and intercellular bridge. Predicted to be part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1051 residues, UniProt reviewed canonical sequence.

>Q6ZP01|RBM44
     1  MQATAVVETA SGKGYHSNGG NLQKDKPSNP KKENLLLSSN GCDEVKLTFP DDDWNSSTLE
    61  QRANNKEISN IDKMDLLEPF FSVSQDTNTE STQFQSSELE DSTDYAFLNK TYSIPYSESK
   121  LKKESLTPLS SELDPEVQKK EEVFFNILEH QDKTVGLERI YNISDANYRE SAEDTQKHDT
   181  DEDSQQEYHS AEEQEYISNH LSFDQTKALD ISNPEVVELG NSGYEVKCAS NVEDNRVNSG
   241  SGSIISFDSL DVYGQEESLH VSKFQNSVML REYHDLKHEK YKEQETNSMY HTVFDGSVLR
   301  SNSPGNQESQ SKSGSLSPQK VLKMKIYTEN MKSQINEGKD FCGNKIVENK ILLHLENPST
   361  LPQDKALETL LQPCKDCQTS WTSVFDDSII SACGYYESLQ NTADSALDFS AMLPKIAVRD
   421  NQAIEDNTSL KVAHSSTTKK TCFHNIGEMC TKSLTDAASC TVTINQTVDV STDFRACFTT
   481  SRATSARPSV VSTSSNTEIT MMNKKRPDEW QNEKQKSVAC STDWSYSEDC IDTQMAITKG
   541  SGKSLSVDSL KPNGNFLNKD FLELRKACGI TDLKKHPERE FQLFKDTEKD LPSMCCQKIM
   601  QRAIKAELHL LNVHYQMCRR HCCDIYKLVM ENREGLNMNL SSNSAKKELG SALLSLLGDL
   661  KVRYVTLKEK IHKGIPLEEL PPLSLESKLL STFSTFASRL MKKETHVFSE ADAEQDNQRA
   721  HDVDVSSNLK KTLSQMSLSS DNSHATQNIS PKKDDFKNGD INADFSQLKL GDKDCRHYQE
   781  TSEDWSDAKE SLTGVDVSGT QGNQVEQDTW NLDLTGEMKN VEPSQRDKGY LIHVGGLCPS
   841  VSEADLRSHF QKYQVSEISI YDSTNYRYAS LAFTKNSDAK IAVKEMNGIE INGKSVNVWP
   901  VKILGEYTSP LSSKNGNRIS SNNLEKSTNK QIHSEFSISR LPRTRPRQLG SEQDSEVFPS
   961  DQGVKKNCKQ IESAKLLPDT PVQFIPPNTL NLRSFTKIIK RLAELHPEVS RDHIINALQE
  1021  VRIRHKGFLN GLSITTIVEM TSSLLKNSAS S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
blood vessel: 0.4 nTPM
bone marrow: 0.4 nTPM
lung: 0.4 nTPM
adipose tissue: 0.3 nTPM
breast: 0.3 nTPM

Single-cell type

early primary spermatocytes: 123 nCPM
differentiating spermatogonia: 68 nCPM
endometrial luminal cells: 38 nCPM
late primary spermatocytes: 29 nCPM
early spermatids: 26 nCPM
late spermatids: 25 nCPM

Immune cell

basophil: 1.3 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.2 nTPM
choroid plexus: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0
gnomAD missense Z: 0.26
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM44 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TEX14

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM44 as an antibody target. Whether an autoantibody or antibody against RBM44 could matter depends on whether native RBM44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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