Seroatlas · Human Serome Atlas

RBM42

RNA-binding protein 42

Also known as: MGC10433, RBM42_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BTD8
Gene
RBM42
Ensembl
ENSG00000126254
Chromosome
19
Canonical length
480 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within negative regulation of mRNA splicing, via spliceosome. Part of U4/U6 x U5 tri-snRNP complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>Q9BTD8|RBM42
     1  MAGAGPAPGL PGAGGPVVPG PGAGIPGKSG EERLKEMEAE MALFEQEVLG APVPGIPTAV
    61  PAVPTVPTVP TVEAMQVPAA PVIRPIIATN TYQQVQQTLE ARAAAAATVV PPMVGGPPFV
   121  GPVGFGPGDR SHLDSPEARE AMFLRRAAVA PQRAPILRPA FVPHVLQRAD SALSSAAAGP
   181  RPMALRPPHQ ALVGPPLPGP PGPPMMLPPM ARAPGPPLGS MAALRPPLEE PAAPRELGLG
   241  LGLGLKEKEE AVVAAAAGLE EASAAVAVGA GGAPAGPAVI GPSLPLALAM PLPEPEPLPL
   301  PLEVVRGLLP PLRIPELLSL RPRPRPPRPE PPPGLMALEV PEPLGEDKKK GKPEKLKRCI
   361  RTAAGSSWED PSLLEWDADD FRIFCGDLGN EVNDDILARA FSRFPSFLKA KVIRDKRTGK
   421  TKGYGFVSFK DPSDYVRAMR EMNGKYVGSR PIKLRKSMWK DRNLDVVRKK QKEKKKLGLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 73 nTPM
  • blood vessel: 66 nTPM
  • skin: 64 nTPM
  • endometrium: 61 nTPM
  • heart muscle: 58 nTPM
  • colon: 57 nTPM

Single-cell type

  • syncytiotrophoblasts: 517 nCPM
  • cytotrophoblasts: 234 nCPM
  • oocytes: 193 nCPM
  • migrating cytotrophoblasts: 181 nCPM
  • esophageal apical cells: 156 nCPM
  • extravillous trophoblasts: 122 nCPM

Immune cell

  • eosinophil: 125 nTPM
  • basophil: 99 nTPM
  • intermediate monocyte: 96 nTPM
  • non-classical monocyte: 95 nTPM
  • myeloid DC: 95 nTPM
  • plasmacytoid DC: 88 nTPM

Brain region

  • medulla oblongata: 65 nTPM
  • white matter: 61 nTPM
  • cerebellum: 60 nTPM
  • basal ganglia: 55 nTPM
  • pons: 53 nTPM
  • thalamus: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.75
gnomAD missense Z
2.39
DepMap mean gene effect
-0.57
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM42 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM42 as an antibody target. Whether an autoantibody or antibody against RBM42 could matter depends on whether native RBM42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBM42. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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