SLTM

Protein identityUniProt · HPA

UniProt accession

Q9NWH9

Gene

SLTM

Ensembl

ENSG00000137776

Chromosome

15

Canonical length

1034 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in regulation of mRNA processing and regulation of transcription by RNA polymerase II. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1034 residues, UniProt reviewed canonical sequence.

>Q9NWH9|SLTM
     1  MAAATGAVAA SAASGQAEGK KITDLRVIDL KSELKRRNLD ITGVKTVLIS RLKQAIEEEG
    61  GDPDNIELTV STDTPNKKPT KGKGKKHEAD ELSGDASVED DAFIKDCELE NQEAHEQDGN
   121  DELKDSEEFG ENEEENVHSK ELLSAEENKR AHELIEAEGI EDIEKEDIES QEIEAQEGED
   181  DTFLTAQDGE EEENEKDIAG SGDGTQEVSK PLPSEGSLAE ADHTAHEEME AHTTVKEAED
   241  DNISVTIQAE DAITLDFDGD DLLETGKNVK ITDSEASKPK DGQDAIAQSP EKESKDYEMN
   301  ANHKDGKKED CVKGDPVEKE ARESSKKAES GDKEKDTLKK GPSSTGASGQ AKSSSKESKD
   361  SKTSSKDDKG STSSTSGSSG SSTKNIWVSG LSSNTKAADL KNLFGKYGKV LSAKVVTNAR
   421  SPGAKCYGIV TMSSSTEVSR CIAHLHRTEL HGQLISVEKV KGDPSKKEMK KENDEKSSSR
   481  SSGDKKNTSD RSSKTQASVK KEEKRSSEKS EKKESKDTKK IEGKDEKNDN GASGQTSESI
   541  KKSEEKKRIS SKSPGHMVIL DQTKGDHCRP SRRGRYEKIH GRSKEKERAS LDKKRDKDYR
   601  RKEILPFEKM KEQRLREHLV RFERLRRAME LRRRREIAER ERRERERIRI IREREERERL
   661  QRERERLEIE RQKLERERME RERLERERIR IEQERRKEAE RIAREREELR RQQQQLRYEQ
   721  EKRNSLKRPR DVDHRRDDPY WSENKKLSLD TDARFGHGSD YSRQQNRFND FDHRERGRFP
   781  ESSAVQSSSF ERRDRFVGQS EGKKARPTAR REDPSFERYP KNFSDSRRNE PPPPRNELRE
   841  SDRREVRGER DERRTVIIHD RPDITHPRHP REAGPNPSRP TSWKSEGSMS TDKRETRVER
   901  PERSGREVSG HSVRGAPPGN RSSASGYGSR EGDRGVITDR GGGSQHYPEE RHVVERHGRD
   961  TSGPRKEWHG PPSQGPSYHD TRRMGDGRAG AGMITQHSSN ASPINRIVQI SGNSMPRGSG
  1021  SGFKPFKGGP PRRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLTM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.62

Highest tissue expression

55 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLTM.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 147 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Jeune thoracic dystrophy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.27

gnomAD pLI

1

gnomAD missense Z

2.53

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• regulation of mRNA processing
• regulation of transcription by RNA polymerase II

Molecular functions

• RNA binding
• sequence-specific DNA binding

Cellular components

• nuclear body
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• SAP domain
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• SAP domain superfamily
• Scaffold Attachment Factor and Modulators
• RNA recognition motif
• SAP domain

KeywordsUniProt

• Acetylation
• Apoptosis
• Coiled coil
• Isopeptide bond
• Methylation
• Nucleus
• Phosphoprotein
• Repressor
• RNA-binding
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of SLTM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CEP19