Seroatlas · Human Serome Atlas

RBM26

RNA-binding protein 26

Also known as: ARRS2, C13orf10, FLJ20957, PPP1R132, PRO1777, RBM26_HUMAN, SE70-2, ZC3H17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T8P6
Gene: RBM26
Ensembl: ENSG00000139746
Chromosome: 13
Canonical length: 1007 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1007 residues, UniProt reviewed canonical sequence.

>Q5T8P6|RBM26
     1  MVSKMIIENF EALKSWLSKT LEPICDADPS ALAKYVLALV KKDKSEKELK ALCIDQLDVF
    61  LQKETQIFVE KLFDAVNTKS YLPPPEQPSS GSLKVEFFPH QEKDIKKEEI TKEEEREKKF
   121  SRRLNHSPPQ SSSRYRENRS RDERKKDDRS RKRDYDRNPP RRDSYRDRYN RRRGRSRSYS
   181  RSRSRSWSKE RLRERDRDRS RTRSRSRTRS RERDLVKPKY DLDRTDPLEN NYTPVSSVPS
   241  ISSGHYPVPT LSSTITVIAP THHGNNTTES WSEFHEDQVD HNSYVRPPMP KKRCRDYDEK
   301  GFCMRGDMCP FDHGSDPVVV EDVNLPGMLP FPAQPPVVEG PPPPGLPPPP PILTPPPVNL
   361  RPPVPPPGPL PPSLPPVTGP PPPLPPLQPS GMDAPPNSAT SSVPTVVTTG IHHQPPPAPP
   421  SLFTADTYDT DGYNPEAPSI TNTSRPMYRH RVHAQRPNLI GLTSGDMDLP PREKPPNKSS
   481  MRIVVDSESR KRTIGSGEPG VPTKKTWFDK PNFNRTNSPG FQKKVQFGNE NTKLELRKVP
   541  PELNNISKLN EHFSRFGTLV NLQVAYNGDP EGALIQFATY EEAKKAISST EAVLNNRFIK
   601  VYWHREGSTQ QLQTTSPKVM QPLVQQPILP VVKQSVKERL GPVPSSTIEP AEAQSASSDL
   661  PQNVTKLSVK DRLGFVSKPS VSATEKVLST STGLTKTVYN PAALKAAQKT LLVSTSAVDN
   721  NEAQKKKQEA LKLQQDVRKR KQEILEKHIE TQKMLISKLE KNKTMKSEDK AEIMKTLEVL
   781  TKNITKLKDE VKAASPGRCL PKSIKTKTQM QKELLDTELD LYKKMQAGEE VTELRRKYTE
   841  LQLEAAKRGI LSSGRGRGIH SRGRGAVHGR GRGRGRGRGV PGHAVVDHRP RALEISAFTE
   901  SDREDLLPHF AQYGEIEDCQ IDDSSLHAVI TFKTRAEAEA AAVHGARFKG QDLKLAWNKP
   961  VTNISAVETE EVEPDEEEFQ EESLVDDSLL QDDDEEEEDN ESRSWRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

lymph node: 38 nTPM
retina: 38 nTPM
cerebellum: 36 nTPM
bone marrow: 35 nTPM
tonsil: 32 nTPM
spleen: 32 nTPM

Single-cell type

lactotrophs: 370 nCPM
gonadotrophs: 350 nCPM
myonuclei: 340 nCPM
somatotrophs: 337 nCPM
thyrotrophs: 320 nCPM
bergmann glia: 311 nCPM

Immune cell

naive B-cell: 5.6 nTPM
naive CD4 T-cell: 4.3 nTPM
basophil: 3.8 nTPM
memory B-cell: 3.7 nTPM
naive CD8 T-cell: 3.7 nTPM
T-reg: 3.3 nTPM

Brain region

cerebellum: 81 nTPM
cerebral cortex: 64 nTPM
basal ganglia: 60 nTPM
white matter: 60 nTPM
hippocampal formation: 55 nTPM
hypothalamus: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 2.53
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Zinc finger, CCCH-type
PWI domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA-binding protein 26/27
PWI domain
RBM26, RNA recognition motif 1
RBM26-like, RNA recognition motif 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SRPK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM26 as an antibody target. Whether an autoantibody or antibody against RBM26 could matter depends on whether native RBM26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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