Seroatlas · Human Serome Atlas

RAVER1

Ribonucleoprotein PTB-binding 1

Also known as: RAVR1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY67
Gene: RAVER1
Canonical length: 606 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RAVER1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

606 residues, UniProt reviewed canonical sequence.

>Q8IY67|RAVER1
     1  MAADVSVTHR PPLSPKSGAE VEAGDAAERR APEEELPPLD PEEIRKRLEH TERQFRNRRK
    61  ILIRGLPGDV TNQEVHDLLS DYELKYCFVD KYKGTAFVTL LNGEQAEAAI NAFHQSRLRE
   121  RELSVQLQPT DALLCVANLP PSLTQQQFEE LVRPFGSLER CFLVYSERTG QSKGYGFAEY
   181  MKKDSAARAK SDLLGKPLGP RTLYVHWTDA GQLTPALLHS RCLCVDRLPP GFNDVDALCR
   241  ALSAVHSPTF CQLACGQDGQ LKGFAVLEYE TAEMAEEAQQ QADGLSLGGS HLRVSFCAPG
   301  PPGRSMLAAL IAAQATALNR GKGLLPEPNI LQLLNNLGPS ASLQLLLNPL LHGSAGGKQG
   361  LLGAPPAMPL LNGPALSTAL LQLALQTQGQ KKPGILGDSP LGALQPGAQP ANPLLGELPA
   421  GGGLPPELPP RRGKPPPLLP SVLGPAGGDR EALGLGPPAA QLTPPPAPVG LRGSGLRGPL
   481  SHFYSGSPTS YFTSGLQAGL KQSHLSKAIG SSPLGSGEGL LGLSPGPNGH SHLLKVRAGG
   541  GDMQGWEAPA PQRPLTRPAL PSVSRPHWAA RNAALPTCCP RPSPAQKAAM WASTPRASAA
   601  TTRTPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAVER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

endometrium: 21 nTPM
small intestine: 21 nTPM
spleen: 20 nTPM
colon: 18 nTPM
ovary: 18 nTPM
bone marrow: 17 nTPM

Single-cell type

pdcs: 15 nCPM
ependymal cells: 14 nCPM
choroid plexus epithelial cells: 14 nCPM
rod photoreceptor cells: 13 nCPM
myonuclei: 12 nCPM
adrenal medulla cells: 11 nCPM

Immune cell

memory CD8 T-cell: 4.6 nTPM
non-classical monocyte: 3.3 nTPM
gdT-cell: 3.2 nTPM
memory CD4 T-cell: 2.7 nTPM
myeloid DC: 2.1 nTPM
total PBMC: 2.1 nTPM

Brain region

medulla oblongata: 26 nTPM
choroid plexus: 23 nTPM
midbrain: 21 nTPM
thalamus: 21 nTPM
basal ganglia: 20 nTPM
pons: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.91
gnomAD missense Z: 1.46
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
Eukaryotic RNA-binding
RNA recognition motif
Ribonucleoprotein PTB-binding 1, RNA recognition motif 1
Ribonucleoprotein PTB-binding 1, RNA recognition motif 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAVER1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAVER1 as an antibody target. Whether an autoantibody or antibody against RAVER1 could matter depends on whether native RAVER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAVER1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAVER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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