Seroatlas · Human Serome Atlas

SRSF3

Serine/arginine-rich splicing factor 3

Also known as: SFRS3, SRp20, SRSF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P84103
Gene
SRSF3
Ensembl
ENSG00000112081
Chromosome
6
Canonical length
164 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>P84103|SRSF3
     1  MHRDSCPLDC KVYVGNLGNN GNKTELERAF GYYGPLRSVW VARNPPGFAF VEFEDPRDAA
    61  DAVRELDGRT LCGCRVRVEL SNGEKRSRNR GPPPSWGRRP RDDYRRRSPP PRRRSPRRRS
   121  FSRSRSRSLS RDRRRERSLS RERNHKPSRS FSRSRSRSRS NERK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
163 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 163 nTPM
  • thymus: 153 nTPM
  • tonsil: 138 nTPM
  • lymph node: 111 nTPM
  • ovary: 95 nTPM
  • esophagus: 92 nTPM

Single-cell type

  • extravillous trophoblasts: 960 nCPM
  • esophageal basal cells: 828 nCPM
  • migrating cytotrophoblasts: 789 nCPM
  • esophageal suprabasal cells: 663 nCPM
  • breast secretory cells: 648 nCPM
  • megakaryocytes: 618 nCPM

Immune cell

  • myeloid DC: 351 nTPM
  • total PBMC: 306 nTPM
  • plasmacytoid DC: 207 nTPM
  • NK-cell: 191 nTPM
  • T-reg: 185 nTPM
  • classical monocyte: 179 nTPM

Brain region

  • white matter: 51 nTPM
  • thalamus: 50 nTPM
  • hypothalamus: 49 nTPM
  • cerebral cortex: 48 nTPM
  • spinal cord: 48 nTPM
  • cerebellum: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.96
gnomAD missense Z
3.07
DepMap mean gene effect
-2.54
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSF3 as an antibody target. Whether an autoantibody or antibody against SRSF3 could matter depends on whether native SRSF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRSF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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