RRP7A

Protein identityUniProt · HPA

UniProt accession

Q9Y3A4

Gene

RRP7A

Ensembl

ENSG00000189306

Chromosome

22

Canonical length

280 aa

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Cell Junctions

OverviewNCBI Gene

Enables RNA binding activity. Involved in cilium disassembly; protein localization to nucleolus; and ribosome biogenesis. Located in several cellular components, including centrosome; cilium; and nuclear lumen. Part of small-subunit processome. Implicated in primary autosomal recessive microcephaly 28. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q9Y3A4|RRP7A
     1  MVARRRKCAA RDPEDRIPSP LGYAAIPIKF SEKQQASHYL YVRAHGVRQG TKSTWPQKRT
    61  LFVLNVPPYC TEESLSRLLS TCGLVQSVEL QEKPDLAESP KESRSKFFHP KPVPGFQVAY
   121  VVFQKPSGVS AALALKGPLL VSTESHPVKS GIHKWISDYA DSVPDPEALR VEVDTFMEAY
   181  DQKIAEEEAK AKEEEGVPDE EGWVKVTRRG RRPVLPRTEA ASLRVLERER RKRSRKELLN
   241  FYAWQHRESK MEHLAQLRKK FEEDKQRIEL LRAQRKFRPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRP7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

27 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RRP7A.

Disease | AllUniProt

Conditions RRP7A is implicated in, by any mechanism.

• Microcephaly 28, primary, autosomal recessive (MCPH28) MIM:619453

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 83 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Microcephaly 28, primary, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.98

gnomAD pLI

0

gnomAD missense Z

-0.35

DepMap mean gene effect

-0.73

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• blastocyst formation
• cilium disassembly
• protein localization to nucleolus
• ribosomal small subunit assembly
• ribosomal small subunit biogenesis
• ribosome biogenesis
• rRNA processing

Molecular functions

• RNA binding

Cellular components

• cell junction
• centrosome
• cilium
• CURI complex
• cytoplasm
• nucleolus
• nucleoplasm
• small-subunit processome
• UTP-C complex

Protein domainsUniProt · Pfam · InterPro

• Nucleotide-binding alpha-beta plait domain superfamily
• Ribosomal RNA-processing protein 7, C-terminal domain
• RNA-binding domain superfamily
• Ribosomal RNA-processing protein 7
• Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain
• Rrp7A, RNA recognition motif
• Rrp7, RRM-like N-terminal domain
• Rrp7 RRM-like N-terminal domain

KeywordsUniProt

• Cell projection
• Cytoplasm
• Cytoskeleton
• Intellectual disability
• Nucleus
• Phosphoprotein
• Primary microcephaly
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of RRP7A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NOL6
• TFIP11