Seroatlas · Human Serome Atlas

RCAN2

Calcipressin-2

Also known as: DSCR1L1, RCAN2_HUMAN, ZAKI-4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14206
Gene
RCAN2
Ensembl
ENSG00000172348
Chromosome
6
Canonical length
197 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Microtubules,Primary cilium,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q14206|RCAN2
     1  MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN
    61  PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG
   121  WQPINDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK
   181  PKIIQTRRPG LPPSVSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCAN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
194 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 194 nTPM
  • heart muscle: 187 nTPM
  • tongue: 168 nTPM
  • cerebral cortex: 102 nTPM
  • midbrain: 85 nTPM
  • parathyroid gland: 80 nTPM

Single-cell type

  • cardiomyocytes: 1,680 nCPM
  • renal collecting duct intercalated cells: 1,641 nCPM
  • myonuclei: 1,222 nCPM
  • vascular smooth muscle cells: 1,220 nCPM
  • salivary ionocytes: 883 nCPM
  • thymic myoid cells: 559 nCPM

Immune cell

  • memory CD8 T-cell: 2.1 nTPM
  • gdT-cell: 1.7 nTPM
  • naive CD8 T-cell: 1.5 nTPM
  • memory CD4 T-cell: 1.1 nTPM
  • total PBMC: 0.4 nTPM
  • basophil: 0 nTPM

Brain region

  • cerebral cortex: 243 nTPM
  • midbrain: 187 nTPM
  • pons: 169 nTPM
  • thalamus: 163 nTPM
  • hypothalamus: 161 nTPM
  • white matter: 151 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.83
gnomAD missense Z
1.18
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCAN2 as an antibody target. Whether an autoantibody or antibody against RCAN2 could matter depends on whether native RCAN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCAN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCAN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RCAN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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