Seroatlas · Human Serome Atlas

SRRT

Serrate RNA effector molecule homolog

Also known as: ARS2, Asr2, serrate, SRRT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXP5
Gene: SRRT
Ensembl: ENSG00000087087
Chromosome: 7
Canonical length: 876 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in primary miRNA processing. Located in nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

876 residues, UniProt reviewed canonical sequence.

>Q9BXP5|SRRT
     1  MGDSDDEYDR RRRDKFRRER SDYDRSRERD ERRRGDDWND REWDRGRERR SRGEYRDYDR
    61  NRRERFSPPR HELSPPQKRM RRDWDEHSSD PYHSGYEMPY AGGGGGPTYG PPQPWGHPDV
   121  HIMQHHVLPI QARLGSIAEI DLGVPPPVMK TFKEFLLSLD DSVDETEAVK RYNDYKLDFR
   181  RQQMQDFFLA HKDEEWFRSK YHPDEVGKRR QEARGALQNR LRVFLSLMET GWFDNLLLDI
   241  DKADAIVKML DAAVIKMEGG TENDLRILEQ EEEEEQAGKP GEPSKKEEGR AGAGLGDGER
   301  KTNDKDEKKE DGKQAENDSS NDDKTKKSEG DGDKEEKKED SEKEAKKSSK KRNRKHSGDD
   361  SFDEGSVSES ESESESGQAE EEKEEAEEAL KEKEKPKEEE WEKPKDAAGL ECKPRPLHKT
   421  CSLFMRNIAP NISRAEIISL CKRYPGFMRV ALSEPQPERR FFRRGWVTFD RSVNIKEICW
   481  NLQNIRLREC ELSPGVNRDL TRRVRNINGI TQHKQIVRND IKLAAKLIHT LDDRTQLWAS
   541  EPGTPPLPTS LPSQNPILKN ITDYLIEEVS AEEEELLGSS GGAPPEEPPK EGNPAEINVE
   601  RDEKLIKVLD KLLLYLRIVH SLDYYNTCEY PNEDEMPNRC GIIHVRGPMP PNRISHGEVL
   661  EWQKTFEEKL TPLLSVRESL SEEEAQKMGR KDPEQEVEKF VTSNTQELGK DKWLCPLSGK
   721  KFKGPEFVRK HIFNKHAEKI EEVKKEVAFF NNFLTDAKRP ALPEIKPAQP PGPAQILPPG
   781  LTPGLPYPHQ TPQGLMPYGQ PRPPILGYGA GAVRPAVPTG GPPYPHAPYG AGRGNYDAFR
   841  GQGGYPGKPR NRMVRGDPRA IVEYRDLDAP DDVDFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRRT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 154 nTPM

Expression across tissuesHPA

Tissue

testis: 154 nTPM
bone marrow: 109 nTPM
liver: 74 nTPM
spleen: 73 nTPM
prostate: 72 nTPM
cerebellum: 70 nTPM

Single-cell type

late spermatids: 450 nCPM
late primary spermatocytes: 313 nCPM
early spermatids: 244 nCPM
erythrocyte progenitors: 95 nCPM
early primary spermatocytes: 90 nCPM
megakaryocyte progenitors: 78 nCPM

Immune cell

memory CD8 T-cell: 39 nTPM
gdT-cell: 28 nTPM
naive CD8 T-cell: 23 nTPM
intermediate monocyte: 23 nTPM
eosinophil: 22 nTPM
total PBMC: 21 nTPM

Brain region

white matter: 50 nTPM
cerebellum: 49 nTPM
medulla oblongata: 48 nTPM
basal ganglia: 47 nTPM
hypothalamus: 47 nTPM
thalamus: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.59
gnomAD missense Z: 2.97
DepMap mean gene effect: -0.85
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA-binding domain superfamily
SERRATE/Ars2 , C-terminal
SERRATE/Ars2, N-terminal
SERRATE/Ars2
Arsenite-resistance protein 2
SERRATE/Ars2, N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRRT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRRT as an antibody target. Whether an autoantibody or antibody against SRRT could matter depends on whether native SRRT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRRT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRRT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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