Seroatlas · Human Serome Atlas

RBM24

RNA-binding protein 24

Also known as: dJ259A10.1, FLJ30829, RBM24_HUMAN, RNPC6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BX46
Gene: RBM24
Ensembl: ENSG00000112183
Chromosome: 6
Canonical length: 236 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables mRNA 3'-UTR AU-rich region binding activity; mRNA CDS binding activity; and sequence-specific mRNA binding activity. Involved in several processes, including negative regulation of cytoplasmic translation; positive regulation of cell differentiation; and regulation of mRNA metabolic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q9BX46|RBM24
     1  MHTTQKDTTY TKIFVGGLPY HTTDASLRKY FEVFGEIEEA VVITDRQTGK SRGYGFVTMA
    61  DRAAAERACK DPNPIIDGRK ANVNLAYLGA KPRIMQPGFA FGVQQLHPAL IQRPFGIPAH
   121  YVYPQAFVQP GVVIPHVQPT AAAASTTPYI DYTGAAYAQY SAAAAAAAAA AAYDQYPYAA
   181  SPAAAGYVTA GGYGYAVQQP ITAAAPGTAA AAAAAAAAAA AFGQYQPQQL QTDRMQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 293 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 293 nTPM
heart muscle: 133 nTPM
tongue: 99 nTPM
endometrium: 29 nTPM
smooth muscle: 27 nTPM
blood vessel: 23 nTPM

Single-cell type

myonuclei: 1,607 nCPM
thymic myoid cells: 216 nCPM
cardiomyocytes: 128 nCPM
vascular smooth muscle cells: 61 nCPM
smooth muscle cells: 42 nCPM
fallopian tube ciliated cells: 39 nCPM

Immune cell

MAIT T-cell: 0.4 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 13 nTPM
hypothalamus: 13 nTPM
basal ganglia: 11 nTPM
hippocampal formation: 10 nTPM
choroid plexus: 7.7 nTPM
amygdala: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0.09
gnomAD missense Z: 1.5
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM24 as an antibody target. Whether an autoantibody or antibody against RBM24 could matter depends on whether native RBM24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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