Seroatlas · Human Serome Atlas

TAF15

TATA-binding protein-associated factor 2N

Also known as: hTAFII68, Npl3, RBP56, RBP56_HUMAN, TAF2N

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92804
Gene
TAF15
Ensembl
ENSG00000270647
Chromosome
17
Canonical length
592 aa
Protein class
Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>Q92804|TAF15
     1  MSDSGSYGQS GGEQQSYSTY GNPGSQGYGQ ASQSYSGYGQ TTDSSYGQNY SGYSSYGQSQ
    61  SGYSQSYGGY ENQKQSSYSQ QPYNNQGQQQ NMESSGSQGG RAPSYDQPDY GQQDSYDQQS
   121  GYDQHQGSYD EQSNYDQQHD SYSQNQQSYH SQRENYSHHT QDDRRDVSRY GEDNRGYGGS
   181  QGGGRGRGGY DKDGRGPMTG SSGGDRGGFK NFGGHRDYGP RTDADSESDN SDNNTIFVQG
   241  LGEGVSTDQV GEFFKQIGII KTNKKTGKPM INLYTDKDTG KPKGEATVSF DDPPSAKAAI
   301  DWFDGKEFHG NIIKVSFATR RPEFMRGGGS GGGRRGRGGY RGRGGFQGRG GDPKSGDWVC
   361  PNPSCGNMNF ARRNSCNQCN EPRPEDSRPS GGDFRGRGYG GERGYRGRGG RGGDRGGYGG
   421  DRSGGGYGGD RSSGGGYSGD RSGGGYGGDR SGGGYGGDRG GGYGGDRGGG YGGDRGGGYG
   481  GDRGGYGGDR GGGYGGDRGG YGGDRGGYGG DRGGYGGDRG GYGGDRSRGG YGGDRGGGSG
   541  YGGDRSGGYG GDRSGGGYGG DRGGGYGGDR GGYGGKMGGR NDYRNDQRNR PY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
115 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 115 nTPM
  • choroid plexus: 84 nTPM
  • esophagus: 84 nTPM
  • thymus: 77 nTPM
  • spinal cord: 74 nTPM
  • lymph node: 73 nTPM

Single-cell type

  • podocytes: 376 nCPM
  • choroid plexus epithelial cells: 332 nCPM
  • renal collecting duct principal cells: 201 nCPM
  • renal collecting duct intercalated cells: 188 nCPM
  • microglia: 188 nCPM
  • oligodendrocytes: 179 nCPM

Immune cell

  • NK-cell: 0.5 nTPM
  • non-classical monocyte: 0.5 nTPM
  • gdT-cell: 0.4 nTPM
  • intermediate monocyte: 0.4 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • T-reg: 0.2 nTPM

Brain region

  • choroid plexus: 48 nTPM
  • midbrain: 43 nTPM
  • hypothalamus: 35 nTPM
  • medulla oblongata: 35 nTPM
  • thalamus: 31 nTPM
  • pons: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.17
gnomAD missense Z
1.22
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF15 as an antibody target. Whether an autoantibody or antibody against TAF15 could matter depends on whether native TAF15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAF15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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