Seroatlas · Human Serome Atlas

PPIL4

Peptidyl-prolyl cis-trans isomerase-like 4

Also known as: PPIL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUA2
Gene
PPIL4
Ensembl
ENSG00000131013
Chromosome
6
Canonical length
492 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q8WUA2|PPIL4
     1  MAVLLETTLG DVVIDLYTEE RPRACLNFLK LCKIKYYNYC LIHNVQRDFI IQTGDPTGTG
    61  RGGESIFGQL YGDQASFFEA EKVPRIKHKK KGTVSMVNNG SDQHGSQFLI TTGENLDYLD
   121  GVHTVFGEVT EGMDIIKKIN ETFVDKDFVP YQDIRINHTV ILDDPFDDPP DLLIPDRSPE
   181  PTREQLDSGR IGADEEIDDF KGRSAEEVEE IKAEKEAKTQ AILLEMVGDL PDADIKPPEN
   241  VLFVCKLNPV TTDEDLEIIF SRFGPIRSCE VIRDWKTGES LCYAFIEFEK EEDCEKAFFK
   301  MDNVLIDDRR IHVDFSQSVA KVKWKGKGGK YTKSDFKEYE KEQDKPPNLV LKDKVKPKQD
   361  TKYDLILDEQ AEDSKSSHSH TSKKHKKKTH HCSEEKEDED YMPIKNTNQD IYREMGFGHY
   421  EEEESCWEKQ KSEKRDRTQN RSRSRSRERD GHYSNSHKSK YQTDLYERER SKKRDRSRSP
   481  KKSKDKEKSK YR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPIL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 34 nTPM
  • ovary: 25 nTPM
  • epididymis: 24 nTPM
  • thyroid gland: 24 nTPM
  • liver: 21 nTPM
  • placenta: 21 nTPM

Single-cell type

  • fallopian secretory cells: 114 nCPM
  • mast cells: 111 nCPM
  • ovarian stromal cells: 109 nCPM
  • extravillous trophoblasts: 104 nCPM
  • syncytiotrophoblasts: 102 nCPM
  • pituicytes/fscs: 101 nCPM

Immune cell

  • basophil: 34 nTPM
  • NK-cell: 32 nTPM
  • naive CD4 T-cell: 25 nTPM
  • memory B-cell: 24 nTPM
  • T-reg: 24 nTPM
  • MAIT T-cell: 21 nTPM

Brain region

  • cerebellum: 48 nTPM
  • hypothalamus: 44 nTPM
  • white matter: 38 nTPM
  • basal ganglia: 38 nTPM
  • cerebral cortex: 37 nTPM
  • midbrain: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
1.4
DepMap mean gene effect
-0.96
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPIL4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPIL4 as an antibody target. Whether an autoantibody or antibody against PPIL4 could matter depends on whether native PPIL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPIL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPIL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPIL4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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