Seroatlas · Human Serome Atlas

RBM43

RNA-binding protein 43

Also known as: C2orf38, FLJ45645, RBM43_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZSC3
Gene: RBM43
Ensembl: ENSG00000184898
Chromosome: 2
Canonical length: 357 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q6ZSC3|RBM43
     1  MASVLNVKES KAPERTVVVA GLPVDLFSDQ LLAVLVKSHF QDIKNEGGDV EDVIYPTRTK
    61  GVAYVIFKEK KVAENVIRQK KHWLARKTRH AELTVSLRVS HFGDKIFSSV NAILDLSVFG
   121  KEVTLETLVK DLKKKIPSLS FSPLKPNGRI SVEGSFLAVK RLRESLLARA CSLLEKDRNF
   181  TSEERKWNRQ NPQRNLQRSN NSLASVRTLV PETARSGEML VLDTDVFLYL KHKCGSYEST
   241  LKKFHILSQE KVDGEITTIC LKSIQVGSQP NNAKHVKELI EEWSHALYLK LRKETFILEG
   301  KENREKRMIK RACEQLSSRY LEVLINLYRT HIDIIGSSSD TYLFKKGVMK LIGQKVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

ovary: 14 nTPM
fallopian tube: 12 nTPM
thyroid gland: 12 nTPM
epididymis: 8.9 nTPM
adrenal gland: 8.2 nTPM
spleen: 7.5 nTPM

Single-cell type

fallopian tube ciliated cells: 66 nCPM
respiratory ciliated cells: 56 nCPM
ovarian stromal cells: 37 nCPM
schwann cells: 34 nCPM
endometrial ciliated cells: 34 nCPM
epididymal principal cells: 29 nCPM

Immune cell

eosinophil: 3 nTPM
NK-cell: 2.7 nTPM
non-classical monocyte: 2.4 nTPM
MAIT T-cell: 2 nTPM
naive CD4 T-cell: 2 nTPM
memory CD4 T-cell: 1.6 nTPM

Brain region

choroid plexus: 8.3 nTPM
medulla oblongata: 7.2 nTPM
midbrain: 7.1 nTPM
spinal cord: 7 nTPM
white matter: 7 nTPM
hypothalamus: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0.13
gnomAD missense Z: 0.83
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

RNA-binding

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM43 as an antibody target. Whether an autoantibody or antibody against RBM43 could matter depends on whether native RBM43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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