Seroatlas · Human Serome Atlas

CPEB1

Cytoplasmic polyadenylation element-binding protein 1

Also known as: CPEB, CPEB1_HUMAN, FLJ13203

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BZB8
Gene
CPEB1
Ensembl
ENSG00000214575
Chromosome
15
Canonical length
566 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>Q9BZB8|CPEB1
     1  MALSLEEEAG RIKDCWDNQE APALSTCSNA NIFRRINAIL DNSLDFSRVC TTPINRGIHD
    61  HLPDFQDSEE TVTSRMLFPT SAQESSRGLP DANDLCLGLQ SLSLTGWDRP WSTQDSDSSA
   121  QSSTHSVLSM LHNPLGNVLG KPPLSFLPLD PLGSDLVDKF PAPSVRGSRL DTRPILDSRS
   181  SSPSDSDTSG FSSGSDHLSD LISSLRISPP LPFLSLSGGG PRDPLKMGVG SRMDQEQAAL
   241  AAVTPSPTSA SKRWPGASVW PSWDLLEAPK DPFSIEREAR LHRQAAAVNE ATCTWSGQLP
   301  PRNYKNPIYS CKVFLGGVPW DITEAGLVNT FRVFGSLSVE WPGKDGKHPR CPPKGNMPKG
   361  YVYLVFELEK SVRSLLQACS HDPLSPDGLS EYYFKMSSRR MRCKEVQVIP WVLADSNFVR
   421  SPSQRLDPSR TVFVGALHGM LNAEALAAIL NDLFGGVVYA GIDTDKHKYP IGSGRVTFNN
   481  QRSYLKAVSA AFVEIKTTKF TKKVQIDPYL EDSLCHICSS QPGPFFCRDQ VCFKYFCRSC
   541  WHWRHSMEGL RHHSPLMRNQ KNRDSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPEB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 32 nTPM
  • testis: 30 nTPM
  • pituitary gland: 19 nTPM
  • midbrain: 16 nTPM
  • hypothalamus: 16 nTPM
  • cerebral cortex: 13 nTPM

Single-cell type

  • oligodendrocytes: 157 nCPM
  • choroid plexus epithelial cells: 102 nCPM
  • ependymal cells: 69 nCPM
  • podocytes: 45 nCPM
  • other brain neurons: 40 nCPM
  • brain excitatory neurons: 28 nCPM

Immune cell

  • naive CD8 T-cell: 1 nTPM
  • memory B-cell: 0.5 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • naive CD4 T-cell: 0.3 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • white matter: 84 nTPM
  • pons: 68 nTPM
  • midbrain: 63 nTPM
  • medulla oblongata: 63 nTPM
  • cerebellum: 60 nTPM
  • thalamus: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
2.1
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CPEB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPEB1 as an antibody target. Whether an autoantibody or antibody against CPEB1 could matter depends on whether native CPEB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPEB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPEB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPEB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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