Seroatlas · Human Serome Atlas

CELF5

CUGBP Elav-like family member 5

Also known as: BRUNOL5, CELF5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6W0
Gene
CELF5
Ensembl
ENSG00000161082
Chromosome
19
Canonical length
485 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q8N6W0|CELF5
     1  MARLTESEAR RQQQQLLQPR PSPVGSSGPE PPGGQPDGMK DLDAIKLFVG QIPRHLDEKD
    61  LKPLFEQFGR IYELTVLKDP YTGMHKGCAF LTYCARDSAI KAQTALHEQK TLPGMARPIQ
   121  VKPADSESRG GRDRKLFVGM LNKQQSEEDV LRLFQPFGVI DECTVLRGPD GSSKGCAFVK
   181  FSSHTEAQAA IHALHGSQTM PGASSSLVVK FADTDKERTL RRMQQMVGQL GILTPSLTLP
   241  FSPYSAYAQA LMQQQTTVLS TSGSYLSPGV AFSPCHIQQI GAVSLNGLPA TPIAPASGLH
   301  SPPLLGTTAV PGLVAPITNG FAGVVPFPGG HPALETVYAN GLVPYPAQSP TVAETLHPAF
   361  SGVQQYTAMY PTAAITPIAH SVPQPPPLLQ QQQREGPEGC NLFIYHLPQE FGDTELTQMF
   421  LPFGNIISSK VFMDRATNQS KCFGFVSFDN PASAQAAIQA MNGFQIGMKR LKVQLKRPKD
   481  PGHPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CELF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 23 nTPM
  • basal ganglia: 22 nTPM
  • cerebral cortex: 22 nTPM
  • hypothalamus: 14 nTPM
  • amygdala: 11 nTPM
  • hippocampal formation: 9.2 nTPM

Single-cell type

  • brain inhibitory neurons: 191 nCPM
  • retinal amacrine cells: 185 nCPM
  • brain excitatory neurons: 148 nCPM
  • other brain neurons: 146 nCPM
  • retinal bipolar cells: 141 nCPM
  • oligodendrocyte progenitor cells: 44 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 89 nTPM
  • hypothalamus: 75 nTPM
  • basal ganglia: 75 nTPM
  • hippocampal formation: 63 nTPM
  • amygdala: 62 nTPM
  • white matter: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
3.69
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CELF5 as an antibody target. Whether an autoantibody or antibody against CELF5 could matter depends on whether native CELF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CELF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CELF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CELF5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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