Seroatlas · Human Serome Atlas

U2SURP

U2 snRNP-associated SURP motif-containing protein

Also known as: fSAPa, SR140, SR140_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15042
Gene: U2SURP
Ensembl: ENSG00000163714
Chromosome: 3
Canonical length: 1029 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in RNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1029 residues, UniProt reviewed canonical sequence.

>O15042|U2SURP
     1  MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP RKHNYRNESA
    61  RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE QEELKKKEDE KAAAEIYEEF
   121  LAAFEGSDGN KVKTFVRGGV VNAAKEEHET DEKRGKIYKP SSRFADQKNP PNQSSNERPP
   181  SLLVIETKKP PLKKGEKEKK KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG
   241  QRRSMDAPSR RNRSSGVLDD YAPGSHDVGD PSTTNLYLGN INPQMNEEML CQEFGRFGPL
   301  ASVKIMWPRT DEERARERNC GFVAFMNRRD AERALKNLNG KMIMSFEMKL GWGKAVPIPP
   361  HPIYIPPSMM EHTLPPPPSG LPFNAQPRER LKNPNAPMLP PPKNKEDFEK TLSQAIVKVV
   421  IPTERNLLAL IHRMIEFVVR EGPMFEAMIM NREINNPMFR FLFENQTPAH VYYRWKLYSI
   481  LQGDSPTKWR TEDFRMFKNG SFWRPPPLNP YLHGMSEEQE TEAFVEEPSK KGALKEEQRD
   541  KLEEILRGLT PRKNDIGDAM VFCLNNAEAA EEIVDCITES LSILKTPLPK KIARLYLVSD
   601  VLYNSSAKVA NASYYRKFFE TKLCQIFSDL NATYRTIQGH LQSENFKQRV MTCFRAWEDW
   661  AIYPEPFLIK LQNIFLGLVN IIEEKETEDV PDDLDGAPIE EELDGAPLED VDGIPIDATP
   721  IDDLDGVPIK SLDDDLDGVP LDATEDSKKN EPIFKVAPSK WEAVDESELE AQAVTTSKWE
   781  LFDQHEESEE EENQNQEEES EDEEDTQSSK SEEHHLYSNP IKEEMTESKF SKYSEMSEEK
   841  RAKLREIELK VMKFQDELES GKRPKKPGQS FQEQVEHYRD KLLQREKEKE LERERERDKK
   901  DKEKLESRSK DKKEKDECTP TRKERKRRHS TSPSPSRSSS GRRVKSPSPK SERSERSERS
   961  HKESSRSRSS HKDSPRDVSK KAKRSPSGSR TPKRSRRSRS RSPKKSGKKS RSQSRSPHRS
  1021  HKKSKKNKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against U2SURP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 54 nTPM
retina: 48 nTPM
ovary: 31 nTPM
thymus: 29 nTPM
lymph node: 28 nTPM
skeletal muscle: 26 nTPM

Single-cell type

early primary spermatocytes: 351 nCPM
erythrocyte progenitors: 323 nCPM
sertoli cells: 248 nCPM
pituicytes/fscs: 242 nCPM
differentiating spermatogonia: 231 nCPM
corticotrophs: 204 nCPM

Immune cell

naive B-cell: 61 nTPM
memory B-cell: 60 nTPM
plasmacytoid DC: 54 nTPM
non-classical monocyte: 49 nTPM
naive CD4 T-cell: 43 nTPM
gdT-cell: 41 nTPM

Brain region

cerebellum: 35 nTPM
white matter: 32 nTPM
cerebral cortex: 28 nTPM
basal ganglia: 25 nTPM
hypothalamus: 24 nTPM
medulla oblongata: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 4.09
DepMap mean gene effect: -1.48
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

RNA processing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

SWAP/Surp
RNA recognition motif domain
CID domain
ENTH/VHS
Nucleotide-binding alpha-beta plait domain superfamily
mRNA splicing factor Cwf21 domain
SWAP/Surp superfamily
RNA-binding domain superfamily
SR-related and CTD-associated factor
RNA recognition motif
Surp module
CID domain
cwf21 domain
SR140, RNA recognition motif
U2-associated protein SR140, cwf21 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of U2SURP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads U2SURP as an antibody target. Whether an autoantibody or antibody against U2SURP could matter depends on whether native U2SURP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

U2SURP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label U2SURP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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