Seroatlas · Human Serome Atlas

RBM25

RNA-binding protein 25

Also known as: fSAP94, NET52, RBM25_HUMAN, RNPC7, S164, Snu71

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49756
Gene: RBM25
Ensembl: ENSG00000119707
Chromosome: 14
Canonical length: 843 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

843 residues, UniProt reviewed canonical sequence.

>P49756|RBM25
     1  MSFPPHLNRP PMGIPALPPG IPPPQFPGFP PPVPPGTPMI PVPMSIMAPA PTVLVPTVSM
    61  VGKHLGARKD HPGLKAKEND ENCGPTTTVF VGNISEKASD MLIRQLLAKC GLVLSWKRVQ
   121  GASGKLQAFG FCEYKEPEST LRALRLLHDL QIGEKKLLVK VDAKTKAQLD EWKAKKKASN
   181  GNARPETVTN DDEEALDEET KRRDQMIKGA IEVLIREYSS ELNAPSQESD SHPRKKKKEK
   241  KEDIFRRFPV APLIPYPLIT KEDINAIEME EDKRDLISRE ISKFRDTHKK LEEEKGKKEK
   301  ERQEIEKERR ERERERERER ERRERERERE REREREKEKE RERERERDRD RDRTKERDRD
   361  RDRERDRDRD RERSSDRNKD RSRSREKSRD RERERERERE RERERERERE RERERERERE
   421  REREREKDKK RDREEDEEDA YERRKLERKL REKEAAYQER LKNWEIRERK KTREYEKEAE
   481  REEERRREMA KEAKRLKEFL EDYDDDRDDP KYYRGSALQK RLRDREKEME ADERDRKREK
   541  EELEEIRQRL LAEGHPDPDA ELQRMEQEAE RRRQPQIKQE PESEEEEEEK QEKEEKREEP
   601  MEEEEEPEQK PCLKPTLRPI SSAPSVSSAS GNATPNTPGD ESPCGIIIPH ENSPDQQQPE
   661  EHRPKIGLSL KLGASNSPGQ PNSVKRKKLP VDSVFNKFED EDSDDVPRKR KLVPLDYGED
   721  DKNATKGTVN TEEKRKHIKS LIEKIPTAKP ELFAYPLDWS IVDSILMERR IRPWINKKII
   781  EYIGEEEATL VDFVCSKVMA HSSPQSILDD VAMVLDEEAE VFIVKMWRLL IYETEAKKIG
   841  LVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 68 nTPM
retina: 39 nTPM
cerebellum: 38 nTPM
skeletal muscle: 38 nTPM
lymph node: 37 nTPM
appendix: 34 nTPM

Single-cell type

endometrial stromal cells: 326 nCPM
neutrophil progenitors: 322 nCPM
erythrocyte progenitors: 309 nCPM
suprabasal keratinocytes: 300 nCPM
basal keratinocytes: 291 nCPM
pituicytes/fscs: 282 nCPM

Immune cell

plasmacytoid DC: 29 nTPM
NK-cell: 27 nTPM
naive B-cell: 24 nTPM
memory B-cell: 22 nTPM
gdT-cell: 20 nTPM
neutrophil: 20 nTPM

Brain region

cerebellum: 63 nTPM
white matter: 61 nTPM
hypothalamus: 59 nTPM
cerebral cortex: 59 nTPM
choroid plexus: 55 nTPM
medulla oblongata: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 4.31
DepMap mean gene effect: -1.47
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
PWI domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
PWI domain superfamily
RNA recognition motif
PWI domain
RBM25, RNA recognition motif
RNA-binding protein 25

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM25 as an antibody target. Whether an autoantibody or antibody against RBM25 could matter depends on whether native RBM25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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