Seroatlas · Human Serome Atlas

RBM3

RNA-binding protein 3

Also known as: IS1-RNPL, RBM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P98179
Gene: RBM3
Ensembl: ENSG00000102317
Chromosome: X
Canonical length: 157 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

157 residues, UniProt reviewed canonical sequence.

>P98179|RBM3
     1  MSSEEGKLFV GGLNFNTDEQ ALEDHFSSFG PISEVVVVKD RETQRSRGFG FITFTNPEHA
    61  SVAMRAMNGE SLDGRQIRVD HAGKSARGTR GGGFGAHGRG RSYSRGGGDQ GYGSGRYYDS
   121  RPGGYGYGYG RSRDYNGRNQ GGYDRYSGGN YRDNYDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 285 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 285 nTPM
adipose tissue: 248 nTPM
breast: 196 nTPM
tonsil: 193 nTPM
skin: 192 nTPM
pancreas: 170 nTPM

Single-cell type

extravillous trophoblasts: 873 nCPM
megakaryocytes: 841 nCPM
migrating cytotrophoblasts: 711 nCPM
esophageal apical cells: 695 nCPM
cytotrophoblasts: 521 nCPM
hofbauer cells: 495 nCPM

Immune cell

myeloid DC: 265 nTPM
total PBMC: 257 nTPM
intermediate monocyte: 213 nTPM
non-classical monocyte: 188 nTPM
classical monocyte: 188 nTPM
plasmacytoid DC: 186 nTPM

Brain region

spinal cord: 46 nTPM
white matter: 46 nTPM
hypothalamus: 44 nTPM
medulla oblongata: 44 nTPM
choroid plexus: 43 nTPM
pons: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.83
gnomAD missense Z: 1.32
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM3 as an antibody target. Whether an autoantibody or antibody against RBM3 could matter depends on whether native RBM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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