Seroatlas · Human Serome Atlas

NXF5

Nuclear RNA export factor 5

Also known as: NXF5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1B4
Gene: NXF5
Canonical length: 397 aa

OverviewNCBI Gene

No narrative summary is available for NXF5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>Q9H1B4|NXF5
     1  MRRNTQDENM RKWFKVTIPY GIKYDKAWLM NSIQSNCSVP FTPVDFHYIR NRACFFVQVA
    61  SAASALKDVS YKIYDDENQK ICIFVSHFTA PYSVKNKLKP GQMEMLKLTM NKRYNVSQQA
   121  LDLQNLRFDP DLMGRDIDII LNRRNCMAAT LKITERNFPE LLSLNLCNNK LYQLDGLSDI
   181  TEKAPKVKTL NLSKNKLESA WELGKVKGLK LEELWLEGNP LCSTFSDQSA YVSAIRDCFP
   241  KLLRLDGREL SAPVIVDIDS SETMKPCKEN FTGSETLKHL VLQFLQQSNL CKYFKDSRNI
   301  KILKDPYLQR KLLKHTKCPR NVDSLSALPE TQHDFTSILV DMWYQTVNTC FLPRAGPESQ
   361  RWWCLLSLKW KDGLRVLILP SCGPSSLPLA AIPVCAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: -0.37

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NXF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXF5 as an antibody target. Whether an autoantibody or antibody against NXF5 could matter depends on whether native NXF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NXF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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