Seroatlas · Human Serome Atlas

HNRNPCL2

Heterogeneous nuclear ribonucleoprotein C-like 2

Also known as: HNRC2_HUMAN, HNRNPCP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
B2RXH8
Gene
HNRNPCL2
Ensembl
ENSG00000275774
Chromosome
1
Canonical length
293 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>B2RXH8|HNRNPCL2
     1  MASNVTNKMD PHSVNSRVFI GNLNTLVVKK SDVEAIFSKY GKIAGCSVHK GFAFVQYDKE
    61  KNARAAVAGE DGRMIASQVA VINLAAEPKV NRGNAGVKRS AAEMYGSSFD LDYGFQRDYY
   121  DGMYSFPARV PPPPPIALAV VPSKRQRISG NTSRRGKSGF NSKSGKRGSS KSGKLKGDDL
   181  QAIKQELTQI KQKVDSLLEN LEKIEKEQSK QEVEVKNAKS EEEQSSSSMK KDETHVKMES
   241  EGGAEDSAEE GDPLDDDDNE DQGDNQLHLI KNNEKDAEEG EDNRDSTNGQ DDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPCL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPCL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPCL2 as an antibody target. Whether an autoantibody or antibody against HNRNPCL2 could matter depends on whether native HNRNPCL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPCL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPCL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HNRNPCL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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