Seroatlas · Human Serome Atlas

RCAN3

Calcipressin-3

Also known as: DSCR1L2, RCAN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKA8
Gene: RCAN3
Ensembl: ENSG00000117602
Chromosome: 1
Canonical length: 241 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Nuclear speckles

OverviewNCBI Gene

Enables phosphatase binding activity and troponin I binding activity. Predicted to be involved in calcium-mediated signaling. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q9UKA8|RCAN3
     1  MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF ACSVHEAVFE
    61  AREQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA ARARIELHET DFNGQKLKLY
   121  FAQVQMSGEV RDKSYLLPPQ PVKQFLISPP ASPPVGWKQS EDAMPVINYD LLCAVSKLGP
   181  GEKYELHAGT ESTPSVVVHV CESETEEEEE TKNPKQKIAQ TRRPDPPTAA LNEPQTFDCA
   241  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCAN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

prostate: 32 nTPM
cerebellum: 28 nTPM
lymph node: 19 nTPM
tonsil: 18 nTPM
stomach: 16 nTPM
thymus: 15 nTPM

Single-cell type

prostatic glandular cells: 378 nCPM
fallopian tube ciliated cells: 218 nCPM
respiratory ciliated cells: 194 nCPM
endometrial ciliated cells: 179 nCPM
alveolar cells type 1: 174 nCPM
t-cells: 168 nCPM

Immune cell

T-reg: 38 nTPM
naive CD4 T-cell: 33 nTPM
memory CD4 T-cell: 25 nTPM
naive CD8 T-cell: 18 nTPM
MAIT T-cell: 10 nTPM
memory CD8 T-cell: 9 nTPM

Brain region

cerebellum: 58 nTPM
pons: 22 nTPM
medulla oblongata: 18 nTPM
midbrain: 18 nTPM
hypothalamus: 18 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of RCAN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCAN3 as an antibody target. Whether an autoantibody or antibody against RCAN3 could matter depends on whether native RCAN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCAN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCAN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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