Seroatlas · Human Serome Atlas

ENOX1

Ecto-NOX disulfide-thiol exchanger 1

Also known as: cCNOX, CNOX, ENOX1_HUMAN, FLJ10094, PIG38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TC92
Gene: ENOX1
Ensembl: ENSG00000120658
Chromosome: 13
Canonical length: 643 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the other is at its lowest. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

643 residues, UniProt reviewed canonical sequence.

>Q8TC92|ENOX1
     1  MVDAGGVENI TQLPQELPQM MAAAADGLGS IAIDTTQLNM SVTDPTAWAT AMNNLGMVPV
    61  GLPGQQLVSD SICVPGFDPS LNMMTGITPI NPMIPGLGLV PPPPPTEVAV VKEIIHCKSC
   121  TLFPQNPNLP PPSTRERPPG CKTVFVGGLP ENATEEIIQE VFEQCGDITA IRKSKKNFCH
   181  IRFAEEFMVD KAIYLSGYRM RLGSSTDKKD SGRLHVDFAQ ARDDFYEWEC KQRMRAREER
   241  HRRKLEEDRL RPPSPPAIMH YSEHEAALLA EKLKDDSKFS EAITVLLSWI ERGEVNRRSA
   301  NQFYSMVQSA NSHVRRLMNE KATHEQEMEE AKENFKNALT GILTQFEQIV AVFNASTRQK
   361  AWDHFSKAQR KNIDIWRKHS EELRNAQSEQ LMGIRREEEM EMSDDENCDS PTKKMRVDES
   421  ALAAQAYALK EENDSLRWQL DAYRNEVELL KQEKEQLFRT EENLTKDQQL QFLQQTMQGM
   481  QQQLLTIQEE LNNKKSELEQ AKEEQSHTQA LLKVLQEQLK GTKELVETNG HSHEDSNEIN
   541  VLTVALVNQD RENNIEKRSQ GLKSEKEALL IGIISTFLHV HPFGANIEYL WSYMQQLDSK
   601  ISANEIEMLL MRLPRMFKQE FTGVGATLEK RWKLCAFEGI KTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENOX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

testis: 8.4 nTPM
skeletal muscle: 7.6 nTPM
ovary: 6.2 nTPM
cerebral cortex: 5.8 nTPM
heart muscle: 4.3 nTPM
placenta: 4.1 nTPM

Single-cell type

oligodendrocytes: 793 nCPM
retinal amacrine cells: 551 nCPM
brain inhibitory neurons: 520 nCPM
brain excitatory neurons: 471 nCPM
medullary thymic epithelial cells: 420 nCPM
late spermatids: 418 nCPM

Immune cell

myeloid DC: 0.3 nTPM
basophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 31 nTPM
cerebral cortex: 29 nTPM
pons: 24 nTPM
medulla oblongata: 22 nTPM
thalamus: 22 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 2.03
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ultradian rhythm

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENOX1 as an antibody target. Whether an autoantibody or antibody against ENOX1 could matter depends on whether native ENOX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENOX1 is annotated at the cell surface, where native ENOX1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ENOX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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