Seroatlas · Human Serome Atlas

ZCRB1

Zinc finger CCHC-type and RNA-binding motif-containing protein 1

Also known as: MADP-1, MADP1, RBM36, SNRNP31, ZCCHC19, ZCRB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TBF4
Gene
ZCRB1
Ensembl
ENSG00000139168
Chromosome
12
Canonical length
217 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q8TBF4|ZCRB1
     1  MSGGLAPSKS TVYVSNLPFS LTNNDLYRIF SKYGKVVKVT IMKDKDTRKS KGVAFILFLD
    61  KDSAQNCTRA INNKQLFGRV IKASIAIDNG RAAEFIRRRN YFDKSKCYEC GESGHLSYAC
   121  PKNMLGEREP PKKKEKKKKK KAPEPEEEIE EVEESEDEGE DPALDSLSQA IAFQQAKIEE
   181  EQKKWKPSSG VPSTSDDSRR PRIKKSTYFS DEEELSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCRB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
179 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 179 nTPM
  • midbrain: 134 nTPM
  • skeletal muscle: 121 nTPM
  • amygdala: 100 nTPM
  • basal ganglia: 95 nTPM
  • hippocampal formation: 90 nTPM

Single-cell type

  • late primary spermatocytes: 960 nCPM
  • early spermatids: 817 nCPM
  • early primary spermatocytes: 332 nCPM
  • parietal cells: 279 nCPM
  • epididymal principal cells: 222 nCPM
  • oocytes: 203 nCPM

Immune cell

  • T-reg: 83 nTPM
  • basophil: 79 nTPM
  • memory B-cell: 68 nTPM
  • plasmacytoid DC: 68 nTPM
  • eosinophil: 65 nTPM
  • naive B-cell: 61 nTPM

Brain region

  • medulla oblongata: 88 nTPM
  • white matter: 83 nTPM
  • spinal cord: 80 nTPM
  • hypothalamus: 75 nTPM
  • pons: 71 nTPM
  • basal ganglia: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.96
DepMap mean gene effect
-0.59
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZCRB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCRB1 as an antibody target. Whether an autoantibody or antibody against ZCRB1 could matter depends on whether native ZCRB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCRB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCRB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZCRB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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