Seroatlas · Human Serome Atlas

TNRC6C

Trinucleotide repeat-containing gene 6C protein

Also known as: FLJ20015, KIAA1582, TNR6C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCJ0
Gene: TNRC6C
Ensembl: ENSG00000078687
Chromosome: 17
Canonical length: 1936 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable RNA binding activity. Involved in miRNA-mediated post-transcriptional gene silencing; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1936 residues, UniProt reviewed canonical sequence.

>Q9HCJ0|TNRC6C
     1  MEEKKKKKQE EKKKKEGAQK KAADQKTKVP EPTKTCSSQP QPAGTSTSTS TSTISSSNNG
    61  KRASASGQQP AASRYLPREV PPRFRQQEQK QLLKRGQPLP TGTLTSVSPT QGAGPAGVSP
   121  PPLPGAGTQH HPSKLQPDLS HSGLADHYEN SHWGQQPTYR SEANCSWDKV IIDRTDKEAW
   181  PSITGTETES ASECTTDTDS ASNCGSENSS MATGSAQGNF TGHTKKTNGN NGTNGALVQS
   241  PSNQSALGAG GANSNGSAAR VWGVATGSSS GLAHCSVSGG DGKMDTMIGD GRSQNCWGAS
   301  NSNAGINLNL NPNANPAAWP VLGHEGTVAT GNPSSICSPV SAIGQNMGNQ NGNPTGTLGA
   361  WGNLLPQEST EPQTSTSQNV SFSAQPQNLN TDGPNNTNPM NSSPNPINAM QTNGLPNWGM
   421  AVGMGAIIPP HLQGLPGANG SSVSQVSGGS AEGISNSVWG LSPGNPATGN SNSGFSQGNG
   481  DTVNSALSAK QNGSSSAVQK EGSGGNAWDS GPPAGPGILA WGRGSGNNGV GNIHSGAWGH
   541  PSRSTSNGVN GEWGKPPNQH SNSDINGKGS TGWESPSVTS QNPTVQPGGE HMNSWAKAAS
   601  SGTTASEGSS DGSGNHNEGS TGREGTGEGR RRDKGIIDQG HIQLPRNDLD PRVLSNTGWG
   661  QTPVKQNTAW EFEESPRSER KNDNGTEAWG CAATQASNSG GKNDGSIMNS TNTSSVSGWV
   721  NAPPAAVPAN TGWGDSNNKA PSGPGVWGDS ISSTAVSTAA AAKSGHAWSG AANQEDKSPT
   781  WGEPPKPKSQ HWGDGQRSNP AWSAGGGDWA DSSSVLGHLG DGKKNGSGWD ADSNRSGSGW
   841  NDTTRSGNSG WGNSTNTKAN PGTNWGETLK PGPQQNWASK PQDNNVSNWG GAASVKQTGT
   901  GWIGGPVPVK QKDSSEATGW EEPSPPSIRR KMEIDDGTSA WGDPSNYNNK TVNMWDRNNP
   961  VIQSSTTTNT TTTTTTTTSN TTHRVETPPP HQAGTQLNRS PLLGPVSSGW GEMPNVHSKT
  1021  ENSWGEPSSP STLVDNGTAA WGKPPSSGSG WGDHPAEPPV AFGRAGAPVA ASALCKPASK
  1081  SMQEGWGSGG DEMNLSTSQW EDEEGDVWNN AASQESTSSC SSWGNAPKKG LQKGMKTSGK
  1141  QDEAWIMSRL IKQLTDMGFP REPAEEALKS NNMNLDQAMS ALLEKKVDVD KRGLGVTDHN
  1201  GMAAKPLGCR PPISKESSVD RPTFLDKDGG LVEEPTPSPF LPSPSLKLPL SHSALPSQAL
  1261  GGIASGLGMQ NLNSSRQIPS GNLGMFGNSG AAQARTMQQP PQPPVQPLNS SQPSLRAQVP
  1321  QFLSPQVQAQ LLQFAAKNIG LNPALLTSPI NPQHMTMLNQ LYQLQLAYQR LQIQQQMLQA
  1381  QRNVSGSMRQ QEQQVARTIT NLQQQIQQHQ RQLAQALLVK QPPPPPPPPH LSLHPSAGKS
  1441  AMDSFPSHPQ TPGLPDLQTK EQQSSPNTFA PYPLAGLNPN MNVNSMDMTG GLSVKDPSQS
  1501  QSRLPQWTHP NSMDNLPSAA SPLEQNPSKH GAIPGGLSIG PPGKSSIDDS YGRYDLIQNS
  1561  ESPASPPVAV PHSWSRAKSD SDKISNGSSI NWPPEFHPGV PWKGLQNIDP ENDPDVTPGS
  1621  VPTGPTINTT IQDVNRYLLK SGGSSPPSSQ NATLPSSSAW PLSASGYSSS FSSIASAPSV
  1681  AGKLSDIKST WSSGPTSHTQ ASLSHELWKV PRNSTAPTRP PPGLTNPKPS STWGASPLGW
  1741  TSSYSSGSAW STDTSGRTSS WLVLRNLTPQ IDGSTLRTLC LQHGPLITFH LNLTQGNAVV
  1801  RYSSKEEAAK AQKSLHMCVL GNTTILAEFA GEEEVNRFLA QGQALPPTSS WQSSSASSQP
  1861  RLSAAGSSHG LVRSDAGHWN APCLGGKGSS ELLWGGVPQY SSSLWGPPSA DDSRVIGSPT
  1921  PLTTLLPGDL LSGESL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNRC6C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

retina: 23 nTPM
thymus: 16 nTPM
cerebral cortex: 9.7 nTPM
skeletal muscle: 9.6 nTPM
testis: 7.9 nTPM
tongue: 7.1 nTPM

Single-cell type

retinal bipolar cells: 510 nCPM
thyrotrophs: 461 nCPM
retinal amacrine cells: 452 nCPM
lactotrophs: 428 nCPM
rod photoreceptor cells: 409 nCPM
oligodendrocyte progenitor cells: 401 nCPM

Immune cell

basophil: 13 nTPM
NK-cell: 2.4 nTPM
naive CD8 T-cell: 1.9 nTPM
MAIT T-cell: 1.6 nTPM
naive CD4 T-cell: 1.6 nTPM
memory CD4 T-cell: 1.5 nTPM

Brain region

cerebellum: 76 nTPM
white matter: 73 nTPM
cerebral cortex: 60 nTPM
basal ganglia: 58 nTPM
amygdala: 55 nTPM
hypothalamus: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 1.65
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
UBA-like superfamily
Nucleotide-binding alpha-beta plait domain superfamily
Ubiquitin-associated domain
Argonaute hook domain
TNRC6, PABC binding domain
RNA-binding domain superfamily
GW182 domain-containing protein
RNA recognition motif
UBA/TS-N domain
Argonaute hook
TNRC6-PABC binding domain
GW182, middle domain
TNRC6C, RNA recognition motif
Trinucleotide repeat-containing gene 6C protein, UBA domain
M domain of GW182

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNRC6C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNRC6C as an antibody target. Whether an autoantibody or antibody against TNRC6C could matter depends on whether native TNRC6C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNRC6C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNRC6C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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