Seroatlas · Human Serome Atlas

ELAVL1

ELAV-like protein 1

Also known as: ELAV1_HUMAN, Hua, HUR, MelG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15717
Gene: ELAVL1
Ensembl: ENSG00000066044
Chromosome: 19
Canonical length: 326 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q15717|ELAVL1
     1  MSNGYEDHMA EDCRGDIGRT NLIVNYLPQN MTQDELRSLF SSIGEVESAK LIRDKVAGHS
    61  LGYGFVNYVT AKDAERAINT LNGLRLQSKT IKVSYARPSS EVIKDANLYI SGLPRTMTQK
   121  DVEDMFSRFG RIINSRVLVD QTTGLSRGVA FIRFDKRSEA EEAITSFNGH KPPGSSEPIT
   181  VKFAANPNQN KNVALLSQLY HSPARRFGGP VHHQAQRFRF SPMGVDHMSG LSGVNVPGNA
   241  SSGWCIFIYN LGQDADEGIL WQMFGPFGAV TNVKVIRDFN TNKCKGFGFV TMTNYEEAAM
   301  AIASLNGYRL GDKILQVSFK TNKSHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELAVL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

thymus: 49 nTPM
testis: 43 nTPM
tonsil: 41 nTPM
lymph node: 38 nTPM
parathyroid gland: 35 nTPM
urinary bladder: 35 nTPM

Single-cell type

late primary spermatocytes: 250 nCPM
early spermatids: 220 nCPM
late spermatids: 214 nCPM
extravillous trophoblasts: 128 nCPM
migrating cytotrophoblasts: 127 nCPM
early primary spermatocytes: 120 nCPM

Immune cell

eosinophil: 37 nTPM
NK-cell: 33 nTPM
basophil: 30 nTPM
naive B-cell: 28 nTPM
memory CD8 T-cell: 26 nTPM
myeloid DC: 25 nTPM

Brain region

choroid plexus: 45 nTPM
white matter: 38 nTPM
spinal cord: 38 nTPM
hypothalamus: 37 nTPM
cerebellum: 37 nTPM
midbrain: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ELAVL1.

Disease | ImmuneIEDB

Conditions an epitope on ELAVL1 was assayed in.

HTLV-1-associated myelopathy/tropical spastic paraparesis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 0.99
gnomAD missense Z: 3.81
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELAVL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELAVL1 as an antibody target. Whether an autoantibody or antibody against ELAVL1 could matter depends on whether native ELAVL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELAVL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELAVL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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