Seroatlas · Human Serome Atlas

RDM1

RAD52 motif-containing protein 1

Also known as: MGC33977, RAD52B, RDM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NG50
Gene
RDM1
Ensembl
ENSG00000278023
Chromosome
17
Canonical length
284 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>Q8NG50|RDM1
     1  MAELVPFAVP IESDKTLLVW ELSSGPTAEA LHHSLFTAFS QFGLLYSVRV FPNAAVAHPG
    61  FYAVIKFYSA RAAHRAQKAC DRKQLFQKSP VKVRLGTRHK AVQHQALALN SSKCQELANY
   121  YFGFNGCSKR IIKLQELSDL EERENEDSMV PLPKQSLKFF CALEVVLPSC DCRSPGIGLV
   181  EEPMDKVEEG PLSFLMKRKT AQKLAIQKAL SDAFQKLLIV VLESGKIAVE YRPSEDIVGV
   241  RCEEELHGLI QVPCSPWKQY GQEEEGYLSD FSLEEEEFRL PELD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RDM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • testis: 11 nTPM
  • thymus: 2.2 nTPM
  • tonsil: 1.3 nTPM
  • basal ganglia: 1 nTPM
  • lymph node: 1 nTPM
  • duodenum: 0.8 nTPM

Single-cell type

  • late spermatids: 114 nCPM
  • early spermatids: 52 nCPM
  • late primary spermatocytes: 23 nCPM
  • early primary spermatocytes: 9.3 nCPM
  • megakaryocytes: 6.2 nCPM
  • megakaryocyte progenitors: 2.6 nCPM

Immune cell

  • memory CD8 T-cell: 2.6 nTPM
  • MAIT T-cell: 1.3 nTPM
  • memory CD4 T-cell: 0.8 nTPM
  • gdT-cell: 0.7 nTPM
  • NK-cell: 0.6 nTPM
  • T-reg: 0.5 nTPM

Brain region

  • cerebellum: 4.3 nTPM
  • basal ganglia: 3.2 nTPM
  • cerebral cortex: 3.1 nTPM
  • hippocampal formation: 3 nTPM
  • hypothalamus: 2.9 nTPM
  • pons: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0
gnomAD missense Z
0.3
DepMap mean gene effect
-0.32
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RDM1 as an antibody target. Whether an autoantibody or antibody against RDM1 could matter depends on whether native RDM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RDM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RDM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RDM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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