Seroatlas · Human Serome Atlas

HNRNPA0

Heterogeneous nuclear ribonucleoprotein A0

Also known as: HNRPA0, ROA0_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13151
Gene: HNRNPA0
Ensembl: ENSG00000177733
Chromosome: 5
Canonical length: 305 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q13151|HNRNPA0
     1  MENSQLCKLF IGGLNVQTSE SGLRGHFEAF GTLTDCVVVV NPQTKRSRCF GFVTYSNVEE
    61  ADAAMAASPH AVDGNTVELK RAVSREDSAR PGAHAKVKKL FVGGLKGDVA EGDLIEHFSQ
   121  FGTVEKAEII ADKQSGKKRG FGFVYFQNHD AADKAAVVKF HPIQGHRVEV KKAVPKEDIY
   181  SGGGGGGSRS SRGGRGGRGR GGGRDQNGLS KGGGGGYNSY GGYGGGGGGG YNAYGGGGGG
   241  SSYGGSDYGN GFGGFGSYSQ HQSSYGPMKS GGGGGGGGSS WGGRSNSGPY RGGYGGGGGY
   301  GGSSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPA0 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 30 nTPM
ovary: 29 nTPM
thymus: 27 nTPM
endometrium: 25 nTPM
adrenal gland: 23 nTPM
cerebellum: 23 nTPM

Single-cell type

extravillous trophoblasts: 605 nCPM
migrating cytotrophoblasts: 473 nCPM
decidual stromal cells: 421 nCPM
basal keratinocytes: 407 nCPM
cytotrophoblasts: 382 nCPM
syncytiotrophoblasts: 379 nCPM

Immune cell

eosinophil: 4.6 nTPM
NK-cell: 4.4 nTPM
MAIT T-cell: 3.4 nTPM
naive CD8 T-cell: 3.2 nTPM
plasmacytoid DC: 3.2 nTPM
memory CD8 T-cell: 3 nTPM

Brain region

cerebellum: 29 nTPM
hypothalamus: 26 nTPM
cerebral cortex: 22 nTPM
white matter: 22 nTPM
basal ganglia: 21 nTPM
pons: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.92
gnomAD missense Z: 2.79
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA recognition motif
hnRNP A0, RNA recognition motif 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPA0 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPA0 as an antibody target. Whether an autoantibody or antibody against HNRNPA0 could matter depends on whether native HNRNPA0 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPA0 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPA0 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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