Seroatlas · Human Serome Atlas

RBM33

RNA-binding protein 33

Also known as: DKFZp434D1319, DKFZp686F102, MGC20460, PRR8, RBM33_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EV2
Gene: RBM33
Ensembl: ENSG00000184863
Chromosome: 7
Canonical length: 1170 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables N6-methyladenosine-containing RNA reader activity and lncRNA binding activity. Involved in RNA export from nucleus and regulation of mRNA stability. Located in cytoplasm. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1170 residues, UniProt reviewed canonical sequence.

>Q96EV2|RBM33
     1  MAAALGASGG AGAGDDDFDQ FDKPGAERSW RRRAADEDWD SELEDDLLGE DLLSGKKNQS
    61  DLSDEELNDD LLQSDNEDEE NFSSQGVTIS LNATSGMVTS FELSDNTNDQ SGEQESEYEQ
   121  EQGEDELVYH KSDGSELYTQ EYPEEGQYEG HEAELTEDQI EYVEEPEEEQ LYTDEVLDIE
   181  INEPLDEFTG GMETLELQKD IKEESDEEEE DDEESGRLRF KTERKEGTII RLSDVTRERR
   241  NIPETLELSA EAKAALLEFE ERERQHKQGR YSSRRGGRRG GPLMCRGVGD QRRESTERGR
   301  MKDHRPALLP TQPPVVPQAP PPPPPPPQQQ PIRSLFQPQP LQPLLPVQHP HHPSPPQGMH
   361  MPPQLETPRM MMTPPPVTPQ QPKNIHINPH FKGTVVTPVQ VPLLPVPSQP RPAVGPQRFP
   421  GPPEFPQHTP GPVPNSFSQP PRLPLQDQWR APPPPQDRDP FFLGVSGEPR FPSHLFLEQR
   481  SPPPPPPPPT LLNSSHPVPT QSPLPFTQPG PAFNQQGQQP VFPRERPVRP ALQPPGPVGI
   541  LHFSQPGSAT TRPFIPPRQP FLPGPGQPFL PTHTQPNLQG PLHPPLPPPH QPQPQQPQQQ
   601  PPPQHQPPHQ PPHQPPPQHQ PPPQHPPQHP PQHQHHHHHH HLSVPPPPLM PMSQPQFRPH
   661  VQTAQPQASS SRMQCPQRQG LRHNTTSQNV SKRPMQQMQP TAPRNSNLRE LPIAPSHVIE
   721  MSSSRCSATP SAQVKPIVSA SPPSRAVAGS RSSQGKTEVK VKPASPVAQP KEEAKTETEF
   781  PDEDEETRLY RLKIEEQKRL REEILKQKEL RRQQQAGARK KELLERLAQQ QQQLYAPPPP
   841  AEQEEQALSP SPTNGNPLLP FPGAQVRQNV KNRLLVKNQD VSISNVQPKT SNFVPSSANM
   901  QYQGQQMKAL KHLRQTRTVP QSQTQPLHKV LPIKPADVEE PAVPQTPRVA SIQGRPQDTK
   961  PGVKRTVTHR TNSGGGDGPH ISSKVRVIKL SGGGGESDGF FHPEGQPQRL PQPPEVGPQP
  1021  ARKVTLTRGG LQQPPHLPAG PHAHSPVPPG IKSIQGIHPA KKAIMHGRGR GVAGPMGRGR
  1081  LMPNKQNLRV VECKPQPCVV SVEGLSSSTT DAQLKSLLMS VGPIQSLQML PQQRKAIAKF
  1141  KEPAHALAFQ QKFHRHMIDL SHINVALIVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 59 nTPM
cerebellum: 41 nTPM
retina: 31 nTPM
liver: 30 nTPM
thymus: 29 nTPM
skeletal muscle: 29 nTPM

Single-cell type

neutrophils: 338 nCPM
neutrophil progenitors: 269 nCPM
proximal tubule cells: 248 nCPM
retinal horizontal cells: 216 nCPM
plasma cells: 213 nCPM
lactotrophs: 208 nCPM

Immune cell

neutrophil: 37 nTPM
basophil: 34 nTPM
eosinophil: 23 nTPM
intermediate monocyte: 11 nTPM
classical monocyte: 10 nTPM
memory B-cell: 9.5 nTPM

Brain region

cerebellum: 132 nTPM
cerebral cortex: 101 nTPM
white matter: 99 nTPM
hypothalamus: 92 nTPM
medulla oblongata: 86 nTPM
thalamus: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 1.8
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA-binding protein 33

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM33 as an antibody target. Whether an autoantibody or antibody against RBM33 could matter depends on whether native RBM33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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