Seroatlas · Human Serome Atlas

RBM10

RNA-binding protein 10

Also known as: DXS8237E, GPATC9, GPATCH9, KIAA0122, RBM10_HUMAN, S1-1, ZRANB5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P98175
Gene: RBM10
Ensembl: ENSG00000182872
Chromosome: X
Canonical length: 930 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

930 residues, UniProt reviewed canonical sequence.

>P98175|RBM10
     1  MEYERRGGRG DRTGRYGATD RSQDDGGENR SRDHDYRDMD YRSYPREYGS QEGKHDYDDS
    61  SEEQSAEDSY EASPGSETQR RRRRRHRHSP TGPPGFPRDG DYRDQDYRTE QGEEEEEEED
   121  EEEEEKASNI VMLRMLPQAA TEDDIRGQLQ SHGVQAREVR LMRNKSSGQS RGFAFVEFSH
   181  LQDATRWMEA NQHSLNILGQ KVSMHYSDPK PKINEDWLCN KCGVQNFKRR EKCFKCGVPK
   241  SEAEQKLPLG TRLDQQTLPL GGRELSQGLL PLPQPYQAQG VLASQALSQG SEPSSENAND
   301  TIILRNLNPH STMDSILGAL APYAVLSSSN VRVIKDKQTQ LNRGFAFIQL STIVEAAQLL
   361  QILQALHPPL TIDGKTINVE FAKGSKRDMA SNEGSRISAA SVASTAIAAA QWAISQASQG
   421  GEGTWATSEE PPVDYSYYQQ DEGYGNSQGT ESSLYAHGYL KGTKGPGITG TKGDPTGAGP
   481  EASLEPGADS VSMQAFSRAQ PGAAPGIYQQ SAEASSSQGT AANSQSYTIM SPAVLKSELQ
   541  SPTHPSSALP PATSPTAQES YSQYPVPDVS TYQYDETSGY YYDPQTGLYY DPNSQYYYNA
   601  QSQQYLYWDG ERRTYVPALE QSADGHKETG APSKEGKEKK EKHKTKTAQQ IAKDMERWAR
   661  SLNKQKENFK NSFQPISSLR DDERRESATA DAGYAILEKK GALAERQHTS MDLPKLASDD
   721  RPSPPRGLVA AYSGESDSEE EQERGGPERE EKLTDWQKLA CLLCRRQFPS KEALIRHQQL
   781  SGLHKQNLEI HRRAHLSENE LEALEKNDME QMKYRDRAAE RREKYGIPEP PEPKRRKYGG
   841  ISTASVDFEQ PTRDGLGSDN IGSRMLQAMG WKEGSGLGRK KQGIVTPIEA QTRVRGSGLG
   901  ARGSSYGVTS TESYKETLHK TMVTRFNEAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 52 nTPM
ovary: 39 nTPM
pituitary gland: 37 nTPM
esophagus: 33 nTPM
spleen: 33 nTPM
prostate: 32 nTPM

Single-cell type

esophageal apical cells: 116 nCPM
cardiomyocytes: 91 nCPM
neutrophils: 86 nCPM
tuft cells: 81 nCPM
neutrophil progenitors: 78 nCPM
syncytiotrophoblasts: 63 nCPM

Immune cell

non-classical monocyte: 16 nTPM
gdT-cell: 13 nTPM
basophil: 13 nTPM
T-reg: 13 nTPM
MAIT T-cell: 12 nTPM
eosinophil: 11 nTPM

Brain region

cerebellum: 39 nTPM
cerebral cortex: 38 nTPM
white matter: 36 nTPM
thalamus: 33 nTPM
hippocampal formation: 30 nTPM
hypothalamus: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RBM10.

Disease | AllUniProt

Conditions RBM10 is implicated in, by any mechanism.

TARP syndrome (TARPS) MIM:311900

Disease | GeneticClinVar

39 pathogenic / likely-pathogenic of 454 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 4.46
DepMap mean gene effect: -0.43
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G-patch domain
RNA recognition motif domain
Zinc finger, RanBP2-type
Nucleotide-binding alpha-beta plait domain superfamily
Zinc finger C2H2-type
RNA-binding domain superfamily
Zinc finger, RanBP2-type superfamily
OCRE domain
RNA recognition motif
Zn-finger in Ran binding protein and others
G-patch domain
OCRE domain
RNA-binding protein 10, RNA recognition motif 2
RBM10, OCRE domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM10 as an antibody target. Whether an autoantibody or antibody against RBM10 could matter depends on whether native RBM10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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