Seroatlas · Human Serome Atlas

SRSF11

Serine/arginine-rich splicing factor 11

Also known as: NET2, p54, SFRS11, SRS11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q05519
Gene
SRSF11
Ensembl
ENSG00000116754
Chromosome
1
Canonical length
484 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

484 residues, UniProt reviewed canonical sequence.

>Q05519|SRSF11
     1  MSNTTVVPST AGPGPSGGPG GGGGGGGGGG GTEVIQVTNV SPSASSEQMR TLFGFLGKID
    61  ELRLFPPDDS PLPVSSRVCF VKFHDPDSAV VAQHLTNTVF VDRALIVVPY AEGVIPDEAK
   121  ALSLLAPANA VAGLLPGGGL LPTPNPLTQI GAVPLAALGA PTLDPALAAL GLPGANLNSQ
   181  SLAADQLLKL MSTVDPKLNH VAAGLVSPSL KSDTSSKEIE EAMKRVREAQ SLISAAIEPD
   241  KKEEKRRHSR SRSRSRRRRT PSSSRHRRSR SRSRRRSHSK SRSRRRSKSP RRRRSHSRER
   301  GRRSRSTSKT RDKKKEDKEK KRSKTPPKSY STARRSRSAS RERRRRRSRS GTRSPKKPRS
   361  PKRKLSRSPS PRRHKKEKKK DKDKERSRDE RERSTSKKKK SKDKEKDRER KSESDKDVKQ
   421  VTRDYDEEEQ GYDSEKEKKE EKKPIETGSP KTKECSVEKG TGDSLRESKV NGDDHHEEDM
   481  DMSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSF11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 64 nTPM
  • bone marrow: 49 nTPM
  • thymus: 46 nTPM
  • ovary: 42 nTPM
  • lymph node: 41 nTPM
  • skeletal muscle: 40 nTPM

Single-cell type

  • sertoli cells: 657 nCPM
  • leydig cells: 454 nCPM
  • syncytiotrophoblasts: 429 nCPM
  • pituicytes/fscs: 409 nCPM
  • peritubular myoid cells: 406 nCPM
  • lactotrophs: 394 nCPM

Immune cell

  • basophil: 104 nTPM
  • eosinophil: 90 nTPM
  • plasmacytoid DC: 75 nTPM
  • NK-cell: 71 nTPM
  • T-reg: 69 nTPM
  • MAIT T-cell: 63 nTPM

Brain region

  • cerebral cortex: 45 nTPM
  • hypothalamus: 38 nTPM
  • cerebellum: 38 nTPM
  • pons: 35 nTPM
  • white matter: 34 nTPM
  • medulla oblongata: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
2.44
DepMap mean gene effect
-1.02
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSF11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSF11 as an antibody target. Whether an autoantibody or antibody against SRSF11 could matter depends on whether native SRSF11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSF11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSF11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRSF11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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