Seroatlas · Human Serome Atlas

NCBP2

Nuclear cap-binding protein subunit 2

Also known as: Cbc2, CBP20, NCBP2_HUMAN, NIP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52298
Gene: NCBP2
Ensembl: ENSG00000114503
Chromosome: 3
Canonical length: 156 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Basal body,Cytosol

OverviewNCBI Gene

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>P52298|NCBP2
     1  MSGGLLKALR SDSYVELSQY RDQHFRGDNE EQEKLLKKSC TLYVGNLSFY TTEEQIYELF
    61  SKSGDIKKII MGLDKMKKTA CGFCFVEYYS RADAENAMRY INGTRLDDRI IRTDWDAGFK
   121  EGRQYGRGRS GGQVRDEYRQ DYDAGRGGYG KLAQNQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

thymus: 47 nTPM
basal ganglia: 46 nTPM
amygdala: 46 nTPM
cerebral cortex: 45 nTPM
midbrain: 43 nTPM
retina: 43 nTPM

Single-cell type

late primary spermatocytes: 119 nCPM
early spermatids: 108 nCPM
gastric progenitor cells: 103 nCPM
extravillous trophoblasts: 95 nCPM
esophageal suprabasal cells: 87 nCPM
esophageal basal cells: 86 nCPM

Immune cell

MAIT T-cell: 57 nTPM
memory B-cell: 53 nTPM
naive CD4 T-cell: 53 nTPM
naive CD8 T-cell: 48 nTPM
non-classical monocyte: 47 nTPM
memory CD4 T-cell: 46 nTPM

Brain region

hypothalamus: 48 nTPM
thalamus: 44 nTPM
spinal cord: 43 nTPM
medulla oblongata: 41 nTPM
white matter: 41 nTPM
midbrain: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.4
gnomAD missense Z: 2.15
DepMap mean gene effect: -1.84
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCBP2 as an antibody target. Whether an autoantibody or antibody against NCBP2 could matter depends on whether native NCBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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