NCBP2L
Nuclear cap-binding protein subunit 2-like
Also known as: NCB2L_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6PVI3
- Gene
- NCBP2L
- Ensembl
- ENSG00000170935
- Chromosome
- X
- Canonical length
- 153 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable RNA cap binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of nuclear cap binding activity complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
153 residues, UniProt reviewed canonical sequence.
>A6PVI3|NCBP2L
1 MSKDLKILCK DPALELSCYR DHQFSGRKFQ QEKLLKESST LNMGNLSFYT TEEKIHELFS
61 RSDIRNIFMG LDKIKKTACG FCFVECHNRA DAENAMRFLT GTCLDEWIIC TDWDVGFREG
121 QQYGRGKSGG QVRDEFREDF HSGRGGFGRQ TQILocalizationUniProt · AlphaFold · HPA
Whether an antibody against NCBP2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 1 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 1 nTPM
- testis: 0.7 nTPM
- fallopian tube: 0.6 nTPM
- ovary: 0.3 nTPM
- salivary gland: 0.3 nTPM
- breast: 0.2 nTPM
Single-cell type
- late primary spermatocytes: 45 nCPM
- epicardial cells: 41 nCPM
- early spermatids: 23 nCPM
- platelets: 17 nCPM
- cardiomyocytes: 9 nCPM
- adipocytes: 5.2 nCPM
Immune cell
- basophil: 8.2 nTPM
- memory B-cell: 0.1 nTPM
- total PBMC: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- white matter: 1.7 nTPM
- cerebral cortex: 1.1 nTPM
- hippocampal formation: 1 nTPM
- amygdala: 0.9 nTPM
- cerebellum: 0.9 nTPM
- thalamus: 0.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.06
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NCBP2L as an antibody target. Whether an autoantibody or antibody against NCBP2L could matter depends on whether native NCBP2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NCBP2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NCBP2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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