TDRD10
Tudor domain-containing protein 10
Also known as: DKFZp434M202, TDR10_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5VZ19
- Gene
- TDRD10
- Ensembl
- ENSG00000163239
- Chromosome
- 1
- Canonical length
- 366 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be active in membrane and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
366 residues, UniProt reviewed canonical sequence.
>Q5VZ19|TDRD10
1 MSWNISHPQL SDKLFGKNGV LEEQKSPGFK KRETEVYVGN LPLDISKEEI LYLLKDFNPL
61 DVHKIQNGCK CFAFVDLGSM QKVTLAIQEL NGKLFHKRKL FVNTSKRPPK RTPDMIQQPR
121 APLVLEKASG EGFGKTAAII QLAPKAPVDL CETEKLRAAF FAVPLEMRGS FLVLLLRECF
181 RDLSWLALIH SVRGEAGLLV TSIVPKTPFF WAMHVTEALH QNMQALFSTL AQAEEQQPYL
241 EGSTVMRGTR CLAEYHLGDY GHAWNRCWVL DRVDTWAVVM FIDFGQLATI PVQSLRSLDS
301 DDFWTIPPLT QPFMLEKDIL SSYEVVHRIL KGKITGALNS AVTAPASNLA VVPPLLPLGC
361 LQQAAALocalizationUniProt · AlphaFold · HPA
Whether an antibody against TDRD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 53 nTPM
Expression across tissuesHPA
Tissue
- testis: 53 nTPM
- thyroid gland: 11 nTPM
- adipose tissue: 10 nTPM
- ovary: 9.9 nTPM
- spleen: 8.6 nTPM
- lung: 7.5 nTPM
Single-cell type
- late spermatids: 332 nCPM
- early spermatids: 173 nCPM
- late primary spermatocytes: 140 nCPM
- early primary spermatocytes: 84 nCPM
- undifferentiated spermatogonia: 48 nCPM
- vascular endothelial cells: 44 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 2.6 nTPM
- thalamus: 2.6 nTPM
- basal ganglia: 2.4 nTPM
- midbrain: 2.1 nTPM
- cerebral cortex: 1.8 nTPM
- choroid plexus: 1.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.92
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.01
- DepMap mean gene effect
- -0.15
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- RNA recognition motif domain
- Tudor domain
- Nucleotide-binding alpha-beta plait domain superfamily
- SNase-like, OB-fold superfamily
- RNA-binding domain superfamily
- RNA recognition motif
- Tudor domain
- Tudor domain-containing protein 10, RNA recognition motif
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TDRD10 as an antibody target. Whether an autoantibody or antibody against TDRD10 could matter depends on whether native TDRD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TDRD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TDRD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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